Scientist II or Senior Scientist, Protein Analytics

Role

Location:

Waltham, MA

We are Alloy Therapeutics — a biotechnology ecosystem and Product Development Organization (PDO) empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma.

At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. May the Best Drug Win.

Alloy has evolved from a startup into a global product development organization operating 11 divisions across 5 research sites in 4 countries on 3 continents. Our model — Integrated Independence — combines centralized capabilities with entrepreneurial operating divisions. Successful members thrive in our shared culture of accountability, deliberate trust, and open communication. As a team we aspire to work together to exceed expectations and collectively contribute across the global organization to always maintain our nimble, startup culture.

At Alloy, we have an ethos of "Mentorship-By-Apprenticeship" in all of our positions. We strive to have workers in the office when needed to interact organically and face-to-face. Of course, as a lab-based operation, our cells and animals grow 7 days a week, 365 days per year. We respect and value our colleagues for their hard work that requires them to be in the lab every day.

We ask our people who have more flexible accommodations to appreciate their colleagues who have less flexibility. We are all one team!

Alloy's Protein Analytics group, within the Alloy Antibody Powered Division, provides analytical support across all analytical activities, including assay development, quality control, high-throughput screening, and detailed characterization of monoclonal and multispecific antibodies, TCRs, TCR mimics, and other modalities.

• Execute:
  Independently design and execute high-throughput screening, stability, forced degradation, and pre-formulation studies to characterize monoclonal and multispecific antibodies and other modalities at various stages of development
• Develop:
  Develop, validate, and optimize advanced analytical methods and workflows for high-throughput screening, stability, forced degradation, and impurity characterization, establishing best practices across the team.
• Deliver:
  Drive later-stage characterization efforts end-to-end, from experimental design through data interpretation, delivering robust stability and develop ability packages that inform key program decisions
• Collaborate:
  Partner across multi-disciplinary teams and Alloy sites, and supervise and mentor junior scientists, reviewing their experimental design and data to ensure quality and consistency
• Communicate:
  Clearly present complex data, conclusions, and recommendations to internal stakeholders and cross-functional teams

• Independently design and execute high-throughput screening, stability, forced degradation, and pre-formulation studies using LC-MS, CE-SDS, CZE/cIEF, DLS, SPRi, BLI, and chromatographic techniques (SEC, HIC, etc.)
• Lead later-stage characterization efforts, including high-concentration stability and impurity characterization studies, to support develop ability and formulation decisions
• Develop and validate new analytical methods, and optimize existing workflows for improved throughput, sensitivity, and reproducibility
• Supervise and mentor junior scientists: providing technical guidance, reviewing experimental designs and data, and supporting their professional development
• Maintain analytical instrumentation and ensure best practices and troubleshooting protocols are followed across the team
• Support protein…