Scientist II or Senior Scientist, Protein Analytics

Role

Location:

Waltham, MA

We are Alloy Therapeutics - a biotechnology ecosystem and Product Development Organization (PDO) empowering the global scientific community to make better medicines together. Through a community of partners, we democratize access to pre-competitive tools, technologies, services, and company creation capabilities that are foundational for discovering and developing therapeutic biologics. The company facilitates affordable, non-exclusive access to the entire drug discovery community from academic scientists, small and medium biotech, to the largest biopharma.

At Alloy, we believe our industry should compete on getting the best drugs to patients as quickly as possible, not exclusive access to the best platforms. As a reflection of our relentless commitment to the scientific community, we reinvest 100% of our revenue in innovation and access to innovation. May the Best Drug Win.

Alloy’s Protein Analytics group, within the Alloy Antibody Powered Division, provides analytical support across all analytical activities, including assay development, quality control, high-throughput screening, and detailed characterization of monoclonal and multispecific antibodies, TCRs, TCR mimics, and other modalities.

We are seeking a highly motivated Scientist or Senior Scientist to conduct biophysical screening and analytical characterization as part of our dynamic, fast-paced biotech team. In this role, you will design & execute high-throughput screening, stability, forced degradation, and pre-formulation experiments using various analytical techniques. You will work collaboratively in a matrixed environment to advance biologics discovery and support rapid, data-driven decision-making.

This role will report to the Head of Protein Analytics and offers significant autonomy, with ownership of multiple stakeholders, projects, and tasks in a dynamic start-up environment, while maintaining the pace and standards of Alloy.

• Execute
  :
  Independently design and execute high-throughput screening, stability, forced degradation, and pre-formulation studies to characterize monoclonal and multispecific antibodies and other modalities at various stages of development.
• Develop
  :
  Develop, validate, and optimize advanced analytical methods and workflows for high-throughput screening, stability, forced degradation, and impurity characterization, establishing best practices across the team.
• Deliver
  :
  Drive later-stage characterization efforts end-to-end, from experimental design through data interpretation, delivering robust stability and develop ability packages that inform key program decisions.
• Collaborate
  :
  Partner across multi-disciplinary teams and Alloy sites, and supervise and mentor junior scientists, reviewing their experimental design and data to ensure quality and consistency.
• Communicate
  :
  Clearly present complex data, conclusions, and recommendations to internal stakeholders and cross-functional teams.

• Independently design and execute high-throughput screening, stability, forced degradation, and pre-formulation studies using LC-MS, CE-SDS, CZE/cIEF, DLS, SPRi, BLI, and chromatographic techniques (SEC, HIC, etc.).
• Lead later-stage characterization efforts, including high-concentration stability and impurity characterization studies, to support develop ability and formulation decisions.
• Develop and validate new analytical methods, and optimize existing workflows for improved throughput, sensitivity, and reproducibility.
• Supervise and mentor junior scientists: providing technical guidance, reviewing experimental designs and data, and supporting their professional development.
• Maintain analytical instrumentation and ensure best practices and troubleshooting protocols are followed across the team.
• Support protein binding assays using BLI (Octet) and SPRi (Carterra LSA), as needed.
• Present experimental data, interpretations, and recommendations during team and cross-functional meetings.
• Ensure timely and successful execution of project activities, proactively identifying and resolving technical challenges.
• Maintain detailed and accurate laboratory records and ensure laboratory organization and compliance with safety protocols.

• Ph.D. with at least 2 years of relevant industry experience, or M.S. with at least 6 years of relevant industry experience.
• Proven track record of expertise in various protein analytical and/or biophysical assessments.
• Hands-on experience with…