Senior Director, Physician Scientist - Immunology & Translational Medicine

CSL Behring is a global biopharmaceutical leader committed to developing innovative therapies for patients with rare and serious diseases. Our Immunology franchise is advancing a diverse pipeline targeting autoimmune and inflammatory conditions across rheumatology, neuroimmunology, and rare dermatology.

Could you be our next Senior Director, Physician Scientist – Immunology & Translational Medicine? The job is in our Waltham MA or Melbourne Australia Office. This is a hybrid position and is onsite three days a week. You will report to the Research Therapeutic Area Lead, Immunology/Transplant and Vaccines.

You will work hands-on as a clinical subject matter expert embedded with the research team, bringing a true bench-to-bedside mindset rather than a purely advisory role. Partnering day-to-day with the Research Therapeutic Area Lead and bench scientists, you will roll up your sleeves to prioritize therapeutic targets, shape clinical development plans, and directly translate mechanistic and preclinical data into first-in-class or best-in-class immunology therapies.

You will be an active, present partner from early ideation through first-in-disease, working shoulder-to-shoulder with discovery research, translational medicine, clinical development, and business development to advance CSL Behring's immunology pipeline.

This is a high-impact role directly influencing portfolio prioritization, target assessment, and early clinical program design through active day-to-day collaboration, not just strategic oversight.

Scientific Leadership & Disease Area Expertise

• Act as the hands-on clinical subject matter expert and internal champion for one or more immunology disease areas, with rheumatology expertise strongly preferred; neuroimmunology and/or dermatology also considered

• Bring a bench-to-bedside mindset, working directly with bench scientists to translate mechanistic understanding of immune pathology into actionable therapeutic hypotheses and target identification strategies

• Sit alongside the research team as an active partner in prioritizing therapeutic targets and building out clinical development plans, not just reviewing decisions after the fact

• Stay personally close to the competitive landscape, emerging science, and unmet medical need across assigned disease areas, digging into primary data and literature directly

• Represent CSL Behring at key scientific conferences, advisory boards, and KOL meetings; build and actively maintain a hands-on network of thought leaders, clinical investigators, and academic collaborators

• Get directly involved end-to-end in asset progression from ideation through first-in-disease designation, personally working through scientific rationale, translational endpoints, patient population selection, and clinical strategy alongside the project team

• Lead or co-lead target and asset evaluation activities, personally reviewing preclinical and clinical data packages, mechanism-of-action assessments, and translational feasibility analyses line by line

• Partner with development colleagues on IND-enabling studies, proof-of-concept study designs, and Phase 1/1b protocol development, working directly with study teams

• Be the go-to immunology clinical subject matter expert embedded with discovery colleagues day-to-day, bridging preclinical science and clinical relevance to directly shape program design and go/no-go decisions

• Work hands-on with discovery and translational teams to define disease-relevant biomarkers, pharmacodynamic readouts, and patient stratification strategies for early clinical programs

• Actively contribute to R&D programs as a working subject matter expert, providing direct, in-the-weeds guidance…