Senior Accountant

Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company harnessing the power of the human immune system to develop transformative therapies for cancer and autoimmune disease. Using its proprietary DECODE™ platform—which maps the immune synapse between T cell receptors (TCRs) and their antigen targets—Repertoire translates unique biological insights into potent and targeted off-the-shelf immune medicines. The company integrates deep protein engineering expertise with artificial intelligence, powered by a proprietary DECODE database of over one billion TCR-antigen interactions, to accelerate discovery and optimize drug candidates.

From its sites in Watertown, Massachusetts and Zurich, Switzerland, Repertoire is advancing a pipeline of T cell-targeted immunotherapies with the potential to address a broad range of cancers and autoimmune disorders. The company’s lead oncology program, RPTR-1-201, a TCR-bispecific, has initiated a Phase 1/2 clinical trial across multiple solid tumor indications. Repertoire plans to advance additional TCR-bispecific therapies into clinical trials over the next 12-18 months.

In autoimmune disease, Repertoire is partnering with leading pharmaceutical companies to develop mRNA tolerizing therapies designed to selectively expand regulatory T cells and reset the immune system.

Repertoire was founded in 2019 by Flagship Pioneering and is supported by a strong investor base. The DECODE platform has been validated through four strategic partnerships with leading pharmaceutical companies—Bristol Myers Squibb, Genentech, Eli Lilly, and Pfizer—representing over $4.5 billion in disclosed total deal value and $185 million in upfront payments received to date.

Repertoire is seeking an experienced Senior Accountant to join our growing Finance team, reporting to the Accounting Manager. This role is well suited to an accountant ready to take ownership of key areas of the monthly close, cash reconciliations, accruals, and accounts payable, while working independently across a broad range of responsibilities and serving as a trusted accounting resource across the organization.

In this role, you will support day-to-day accounting operations, play a key role in the monthly close process, and help strengthen our financial infrastructure as the Company continues to grow. We are looking for a colleague who is excited to contribute to our collaborative culture and values working alongside teammates in our Watertown office for a minimum of three days per week.

• Assist with the timely completion of the month-end close through the preparation of journal entries, account reconciliations, and period-over-period account fluctuation analyses.
• Responsible for the monthly cash reconciliation process.
• Maintain fixed asset, lease, and other current asset schedules.
• Facilitate the monthly purchase order accrual process, collaborating with external vendors and internal business stakeholders, including FP&A.
• Partner with the Accounting Manager to estimate and record monthly material accruals.
• Collaborate with outsourced Accounts Payable to resolve vendor and billing issues.
• Responsible for weekly check runs and monitor accounts payable to ensure invoices are recorded, approved, and paid on time.
• Support the preparation of financial statement audits, tax compliance reporting, and other regulatory filings, as needed.
• Support the maintenance and implementation of internal controls, including identifying opportunities for process improvements and operational efficiencies within areas of responsibility.
• Ensure accounting records are complete, accurate, and maintained in accordance with U.S. GAAP and Company policies.
• Participate in special…