Associate Director, Human Resources

Associate Director, Human Resources
Company Overview

Repertoire Immune Medicines is a clinical-stage biotechnology company harnessing the power of the human immune system to develop transformative therapies for cancer and autoimmune disease. Using its proprietary DECODE™ platform — which maps the immune synapse between T cell receptors (TCRs) and their antigen targets — Repertoire translates unique biological insights into potent and targeted off-the-shelf immune medicines. The company integrates deep protein engineering expertise with artificial intelligence, powered by a proprietary DECODE database of over one billion TCR-antigen interactions, to accelerate discovery and optimize drug candidates.

From its sites in Watertown, Massachusetts and Zurich, Switzerland, Repertoire is advancing a pipeline of T cell-targeted immunotherapies with the potential to address a broad range of cancers and autoimmune disorders. The company's lead oncology program, RPTR-1-201, a TCR bispecific, has initiated a Phase 1/2 clinical trial across multiple solid tumor indications. Repertoire plans to advance additional TCR bispecific therapies into clinical trials over the next 12-18 months.

In autoimmune disease, Repertoire is partnering with leading pharmaceutical companies to develop mRNA tolerizing therapies designed to selectively expand regulatory T cells and reset the immune system.

Repertoire was founded in 2019 by Flagship Pioneering and is supported by a strong investor base. The DECODE platform has been validated through four strategic partnerships with leading pharmaceutical companies — Bristol Myers Squibb, Genentech, Eli Lilly, and Pfizer — representing over $4.5 billion in disclosed total deal value and $185 million in upfront payments received to date.

The Associate Director, Human Resources is the second member of the HR function and partners directly with the VP of Human Resources to build, operate, and scale the people infrastructure of a growing, two-country biotech. This on-site role holds end-to-end accountability for HR operations, benefits and total rewards administration, employment compliance, talent acquisition, and day-to-day business partnership with functional leaders and their teams.

This is a broad, hands-on role. The Associate Director executes transactional work — Form I-9 completion, interview scheduling, benefits reconciliation, HRIS data entry — while designing the processes, policies, and systems that will allow the function to scale. Success in this role requires a professional who is equally comfortable conducting a payroll audit and advising a VP on team dynamics.

• Own and optimize HR systems (ADP,  ATS, and related platforms), ensuring data integrity, audit readiness, and regulatory compliance across both sites.
• Manage full employee lifecycle processes including onboarding, offboarding, promotions, job changes, immigration and visa processing, and benefits enrollment.
• Partner with Finance on semi-monthly U.S. payroll processing and reconciliations, and with Swiss leadership on payroll adjustments as needed.
• Develop HR dashboards, people analytics, and executive reporting for the VP of HR and leadership.

• Own and maintain the HR Compliance Calendar ensuring timely filings, notices, audits, and regulatory actions.
• Ensure U.S. compliance with wage and hour laws, ERISA, ACA, COBRA, I-9, E-Verify, Workers' Compensation, Massachusetts Paid Family and Medical Leave, and salary range transparency requirements.
• Working with Swiss leadership, ensure compliance with Swiss employment law, including written employment contracts, and working time and vacation entitlements.

• Own the employee…