Senior​/Principal Scientist

Overview

Orna Therapeutics is an innovative biotechnology startup based in Watertown, MA, committed to developing groundbreaking therapies for diseases that current approaches cannot address. With our pioneering circular RNA technology, developed at MIT, we are at the forefront of advancing the next generation of RNA therapeutics. Our state-of-the-art expression and delivery platform positions us to tackle complex diseases, including B cell-driven autoimmune disorders, B cell malignancies, sickle cell disease, and beyond.

We are looking for a talented and driven Senior/Principal Scientist to join our RNA Production Research Optimization (P.R.O.) team within the Platform Research department. This is a unique opportunity to contribute to the development of next-gen RNA-based therapeutics while expanding your expertise in a fast-paced, cutting-edge field. As a key member of the team, you will play a critical role in in-vivo scale RNA optimization with a primary focus on circular-RNA purity improvement and next-generation product development.

• The candidate will be responsible for the development of in-vitro transcription (IVT) conditions and purification processes for circular-RNA-based therapeutics to support various programs.
• Optimize reactions, starting materials, and process conditions.
• Contribute to downstream process development for purification of circular-RNA.
• Develop circular-RNA analytics for purity determination and impurity profiling.
• Ability to supervise and mentor junior team members.
• Cross-train team members in RNA synthesis and purification.

• PhD in Molecular Biology, Biochemistry, or a related field with 5+ years of industry experience or master’s degree with 10+ years of specialized experience
• Demonstrated success in the purification of circular RNA from IVT reactions, specifically utilizing chromatography and filtration techniques.
• Deep theoretical knowledge and robust hands-on experience with RNA splicing mechanisms and ribozyme biochemistry
• In-depth knowledge of nucleic acid/oligonucleotides chemistry and standard analytical methods of these molecules.
• A comprehensive foundation in cell biology is essential for this role.
• Proven track record of managing and mentoring high-performing, motivated technical teams.
• Hands-on experience with AKTA purifier with solid knowledge of Unicorn software.
• The applicant should have strong communication and collaboration skills, along with multiple examples of a strong technical background.
• Experience with bacterial and mammalian cell culture.
• Experience with analytical techniques like ELISA, CE, HPLC, LC-MS.

At Orna Therapeutics, we’re more than just a workplace—we’re a community. We believe in fostering an environment where individuals can grow, thrive, and make a lasting impact on the future of healthcare. Join us as we revolutionize RNA therapeutics and make a difference in the lives of patients around the world.

Individuals seeking employment at Orna Therapeutics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

The expected salary range for this position as Senior Scientist is $125,860 - $161,258

The expected salary range for this position as Principal Scientist is $142,100 - $182,065

Orna considers a variety of factors when determining base compensation, including experience, qualifications, market data and internal equity. These considerations mean actual compensation may vary. This position will be eligible for an annual target bonus percentage and equity based on job level, generous time off policies, and a comprehensive benefits package. Review Orna’s benefits here .

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