Principal Scientist, Structural Biology

Role Summary

C4 Therapeutics is seeking a highly motivated and innovative scientist to apply cutting edge structural biology techniques to the discovery, characterization, and development of small molecule targeted protein degraders. You will leverage your extensive experience and in-depth knowledge of how structural biology, biochemistry, and biophysics can be creatively and successfully applied to challenging drug discovery and development efforts. You will manage external CROs to support mechanistic understanding and optimization of monovalent and bivalent molecules that promote ternary complex formation between E3 ligases and drivers of disease leading to their efficient ubiquitination and degradation.

• Maintain state-of-the-art capabilities for structural biology through managing CROs in order to support E3 ligase and therapeutic target ligand discovery and optimization, binary and ternary complex characterization and small molecule degrader design
• Contribute to drug discovery projects using X-ray crystallography and cryo-EM techniques through management of our CRO partners
• Contribute structural biology guidance in both the design of protein constructs used in hit identification screens and in further compound progression efforts
• Establish and maintain strong productive relationships with strategic partners and collaborators
• Work as a leader and colleague across functional areas to help drive structure-based drug discoveries throughout our portfolio

• Required:
  
  A PhD in Structural Biology, Biophysics, or a related field with a minimum of eight years of experience in a Life Science setting; additional experience can compensate for required education
• Required:
  
  Deep understanding and extensive experience with X-ray crystallography
• Required:
  
  Familiarity with in vitro biochemical and biophysical methods such as SPR, FP, FRET, ITC, and their application to structure activity relationships
• Required:
  
  Experience with small-molecule drug discovery and effectively introducing relevant new technologies to a company environment
• Required:
  
  Experience in managing CROs
• Preferred:
  
  Experience with cryo
  
  EM and/or familiarity with other structural methods such as HDX-MS and SAXS
• Preferred:
  Experience with DNA encoded library (DEL) platforms