Director, DMPK

At Foghorn Therapeutics, we believe in "People First, Mission Always."

We put "People First" because we know our people are the key to everything we will accomplish. We value the diversity of background, ideas, perspectives and experiences that our team members bring to Foghorn Therapeutics — demonstrated by our community speaking more than 22 languages and representing over 24 nationalities. We value our teammates as people, not just as employees — validated by our actions that let our people know that we care about them, their families, and their lives.

We say "Mission Always" because we know a relentless commitment to our mission will make a difference in the lives of others. We believe our success will come from evaluating the data to follow the science. We work hard to develop a new class of therapies that could improve the lives of over 2.5 million people with cancer.

Our culture is focused on succeeding through the evaluation of data, not people. And in that, relationships can flourish and develop.

The groundbreaking science behind our therapies continues to yield vital insights into diseases that have confounded physicians and researchers. Our core scientific approach is centered on the chromatin regulatory system, which opens and closes the right sections of DNA at the right time. Breakdowns in the chromatin regulatory system lead to a wide range of diseases, including cancer, impacting millions of people.

Our proprietary Gene Traffic Control® platform is a powerful tool for understanding and modulating the chromatin regulatory system. We are pursuing multiple treatments for breakdowns in this system. We are the only company with the ability to study and target the chromatin regulatory system at scale, in context, and in an integrated way.

This position offers an exciting opportunity to be a key part of a research and development organization that is pioneering a new class of medicines. The Director, DMPK project representative, will provide direct support to multiple project teams across the discovery and early clinical development portfolio.

• Design and execute issue-driven ADME/PK studies to address critical discovery project needs, supporting program progression through lead optimization to early development
• Analyze and interpret preclinical ADME/PK data, communicating results and recommendations to project teams effectively
• Build and maintain strong collaborations with internal and external partners across chemistry, biology, pharmacology, CMC and other R&D disciplines
• Partner with discovery and clinical groups to design preclinical studies that inform clinical dosing strategy
• Contribute to key decisions including candidate selection, development strategy, and clinical trial design
• Author and review preclinical study reports, including nonclinical toxicology, DMPK and biomarker sections of regulatory documents
• Design and interpret PK/PD, efficacy and toxicology studies in collaboration with cross‑functional teams
• Stay current with DMPK scientific literature and emerging technologies to identify potential applications for ongoing programs
• Help finalize clinical study protocols and reports with focus on DMPK aspects

• PhD or equivalent in relevant field
• 7+ years of experience in a pharmaceutical/biotechnology setting
• Strong understanding of DMPK principles and ADME/PK assays in drug development
• Demonstrated expertise in human PK and dose projections
• Proven track record as DMPK project representative/leader on multiple project teams
• Up‑to‑date knowledge of regulatory guidance related to ADME/PK characterization, drug‑drug interaction, and human ADME studies
• Experience with IND preparation and other regulatory documents
• Strong communication and collaboration skills with ability to effectively convey ADME/PK risks
• Experience with covalent modalities, PROTACs and parenteral delivery preferred
• Demonstrated ability to work effectively in cross‑functional team environments

• Foghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:
  • Highly competitive and inclusive medical, dental and vision coverage…