More jobs:
Associate Scientist/Sr. Associate Scientist/Scientist, Islet Process Sciences
Job in
Watertown, Middlesex County, Massachusetts, 02472, USA
Listed on 2026-07-09
Listing for:
Scorpion Therapeutics
Full Time
position Listed on 2026-07-09
Job specializations:
-
Research/Development
Research Scientist, Biotech Research
Job Description & How to Apply Below
Role Overview
- Execute iPSC maintenance, scale-up preparation, 3D aggregate culture, and directed differentiation toward pancreatic islet-like cell populations.
- Design, run, and troubleshoot suspension-based differentiation experiments in scalable formats (including PBS Vertical Wheel bioreactors when appropriate).
- Operate controlled bioreactor systems and monitor inputs (pH, dissolved oxygen, agitation, inoculation density, feeding strategy, media exchange, culture timing).
- Innovate across workflow: signaling timing; growth factor/cytokine conditions; media/feed strategies; aggregate handling; cryopreservation/recovery; and culture-format changes to improve cell fate, scalability, and performance.
- Develop and optimize process parameters to improve endocrine commitment, beta cell identity, reproducibility, recovery, cryopreservation compatibility, and scalability.
- Apply Quality by Design and DOE to link biological outcomes to controllable variables; define CQAs/CPPs and operating ranges for scale-up/manufacturing readiness.
- Generate/interpret analytical readouts (RT-qPCR, intracellular flow cytometry, immunofluorescence imaging, ELISA, viability, metabolites, aggregate-size).
- Support standardized closed/semi-closed manufacturing-relevant workflows using single-use components and sterile/aseptic systems; maintain E‑Lab documentation/SOPs/batch records; present data and propose next‑step experiments; maintain safe, compliant lab environment.
- Associate Scientist: BS/MS (bioengineering, chemical engineering, biology, stem cell biology, or related) with ~2–5+ years.
- Scientist: MS/PhD with ~3–8+ years.
- Hands‑on human pluripotent stem cell culture (2D + 3D aggregate/suspension) and directed differentiation experience in scalable/process‑development settings.
- Bioreactor experience (setup/sampling/monitoring/control); experience with assays (flow cytometry, RT‑qPCR, imaging, ELISA, etc.).
- Ability to analyze data, troubleshoot variability, and translate findings into process recommendations.
- Strong documentation and communication; able to work independently with cross‑functional partners.
- Approx. $115,000–$150,000/year depending on level/experience.
- Annual performance bonus.
- Medical/dental/vision.
- 401K match.
- 20+ days PTO/year (prorated).
- US work authorization.
Position Requirements
10+ Years
work experience
To View & Apply for jobs on this site that accept applications from your location or country, tap the button below to make a Search.
(If this job is in fact in your jurisdiction, then you may be using a Proxy or VPN to access this site, and to progress further, you should change your connectivity to another mobile device or PC).
(If this job is in fact in your jurisdiction, then you may be using a Proxy or VPN to access this site, and to progress further, you should change your connectivity to another mobile device or PC).
Search for further Jobs Here:
×