Principal Scientist, Biology; Immunology

Your Role

• Lead one or more autoimmune-focused discovery programs, from target identification through candidate selection, including experimental strategy and milestones to generate robust translational data packages and support progression toward development
• Integrate biology, pharmacology, and chemistry data to enable data-driven decisions and portfolio prioritization
• Identify and validate novel targets and pathways driving autoimmune disease biology, maintaining deep awareness of emerging trends in immunology and autoimmune disease biology
• Design and execute in vitro, ex vivo, and in vivo studies to support validation and differentiation of degraders as well as their mechanism of action
• Collaborate closely with team members within and across functional areas to achieve key company goals
• Analyze, summarize, and present data at team meetings and broader project team meetings
• Build and manage academic and industry collaborations
• Mentor/develop junior scientists and provide technical leadership and foster a culture of scientific rigor and innovation

Required:

• Ph.D. in Immunology, Cell Biology, or related discipline with a minimum of ten years of industry experience in biotechnology or pharmaceutical drug discovery
• Demonstrated success leading autoimmune or inflammatory disease programs
• Deep expertise in immune cell biology (e.g., T cells, myeloid cells, immune regulation), inflammatory/autoimmune disorders, and cellular and molecular assay design
• Strong record of scientific achievement (publications, patents, or pipeline contributions)

Preferred:

• Experience in CRO management
• Experience with targeted protein degradation
• Experience developing human-relevant translational models (ex vivo systems, patient-derived samples, or complex immune assays)

Base pay range: $ to $ annually at commencement of employment (may vary by knowledge, skills, and experience).