Senior Research Associate

Senior Research Associate - xRNA Process Sciences

Location: Watertown, MA

Job Type: Full-Time | Lab & Office-Based

We are seeking a motivated Senior Research Associate to join a growing Process Sciences team focused on the development and manufacturing of xRNA-based therapeutics
. This role is ideal for a hands-on scientist with experience in mRNA/xRNA process development, IVT, downstream purification, and process scale-up
.

You will play an important role in developing, optimizing, and supporting RNA production processes from laboratory through intermediate scale, while contributing to analytical testing, troubleshooting, and technology transfer activities.

• Perform and support in vitro transcription (IVT) reactions at small and intermediate scales.
• Support IVT processes using stirred-tank and wave-based systems
  .
• Troubleshoot and optimize IVT and downstream purification processes.
• Perform and support chromatography-based purification of IVT-produced RNA.
• Execute and support AKTA-based purification processes
  .
• Perform tangential flow filtration (TFF) and related downstream processing activities.
• Support process development, optimization, scale-up, and technology transfer activities.
• Evaluate RNA purity and concentration using analytical techniques including Fragment Analyzer, Nano Drop, CE, Bioanalyzer, gel electrophoresis, and UV spectroscopy
  .
• Maintain accurate and thorough laboratory documentation in accordance with good documentation practices.
• Follow GLP/GMP principles, laboratory safety procedures, and applicable BSL requirements
  .
• Collaborate with cross-functional teams to support internal programs and client-facing projects.
• Contribute to troubleshooting, process improvement, and other activities as required.

• Bachelor’s degree in Pharmaceutical Sciences, Engineering, or a related discipline with 1-2 years of relevant hands-on experience,
  or a Master’s degree with relevant industry or academic experience.
• Hands-on experience with mRNA/xRNA drug substance process development and/or manufacturing processes.
• Practical experience with IVT and RNA process development
  .
• Experience with AKTA chromatography and purification process development/optimization
  .
• Hands-on experience with TFF
  , including process development, scale-up, or technology transfer.
• Experience with RNA characterization and analytical techniques such as Fragment Analyzer/CE, Bioanalyzer, gel electrophoresis, UV spectroscopy, or Nano Drop
  .
• Understanding of pharmaceutical/biotechnology processes and laboratory best practices.
• Strong troubleshooting and problem-solving abilities.
• Excellent written and verbal communication skills.
• Ability to work effectively in a collaborative, fast-paced laboratory environment.