Advisor, Drug Product Process Development

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism.

We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world. Overview:
At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism. Orna Therapeutics, Inc., a wholly owned subsidiary of Eli Lilly and Company, is an innovative biotechnology startup based in Watertown, MA, committed to developing groundbreaking therapies for diseases that current approaches cannot address.

With our pioneering circular RNA technology, developed at MIT, we are at the forefront of advancing the next generation of RNA therapeutics. Our state-of-the-art expression and delivery platform positions us to tackle complex diseases, including B cell-driven autoimmune disorders, B cell malignancies, sickle cell disease, and beyond.

Position Summary:

The successful candidate will design, execute, and oversee experiments for the technical development and scale-up of lipid nanoparticle (LNP) drug product processes.

This role offers a unique opportunity to independently drive LNP platform science within Orna, identify knowledge gaps, and translate cutting-edge formulation science into robust, scalable manufacturing processes. The ideal candidate will have a strong background in carrier-based drug product development, process optimization, scale-up, and technical transfer. They will possess excellent oral and written communication capabilities, demonstrate strong collaboration and interpersonal skills, and be adept at problem solving in a fast-paced, innovation-driven environment.

Responsibilities:
The successful candidate will design, execute, and oversee experiments for the technical development and scale-up of lipid nanoparticle (LNP) drug product processes.

This role offers a unique opportunity to independently drive LNP platform science within Orna, identify knowledge gaps, and translate cutting-edge formulation science into robust, scalable manufacturing processes. The ideal candidate will have a strong background in carrier-based drug product development, process optimization, scale-up, and technical transfer. They will possess excellent oral and written communication capabilities, demonstrate strong collaboration and interpersonal skills, and be adept at problem solving in a fast-paced, innovation-driven environment.

Basic Requirements:
* PhD, MS, or BS degree in chemical engineering, biomedical engineering, pharmaceutical sciences, chemistry, biology, or a related field with the following years of industry experience:
PhD 0-5 years, MS 7+ years, or BS 10+ years.
* Demonstrated hands-on experience in formulation and process development particularly in carrier-based or complex drug product systems (e.g., lipid nanoparticles, liposomes, emulsions, microspheres, or other advanced delivery platforms).
* Working knowledge of fluid mixing dynamics, particle self-assembly, and surface chemistry concepts, including common characterization methods (e.g. DLS, Ribogreen, Cryo-EM etc.)
* Track record of independently designing and executing experiments; ability to proactively identify scientific knowledge gaps and propose structured plans to address them. Additional Preferences:
* Experience with multiple filtration technologies such as TFF hollow fibers, flat sheets, and depth filtration a plus.
* Experience working within a matrixed CMC environment, including cross-functional collaboration with manufacturing, analytical development, and…