Scientist - Cell Engineering

About Astellas

Astellas is a global life sciences company committed to turning innovative science into VALUE for patients. We provide transformative therapies in disease areas that include oncology, ophthalmology, urology, immunology and women's health. Through our research and development programs, we are pioneering new healthcare solutions for diseases with high unmet medical need. Learn more at

Astellas is a global life sciences company committed to turning innovative science into VALUE for patients. We provide transformative therapies in disease areas that include oncology, ophthalmology, urology, immunology and women's health. Through our research and development programs, we are pioneering new healthcare solutions for diseases with high unmet medical need. Learn more at

We're seeking passionate individuals who thrive in dynamic environments, embrace new ideas, and aren't afraid to take intelligent risks. People who act with unwavering integrity and are deeply committed to making a tangible impact.

The Scientist I, contributes to the development and characterization of engineered cell therapeutics through the design, execution, analysis, and interpretation of in vitro studies. The incumbent will support platform and candidate advancement by generating high-quality scientific data, developing and implementing characterization approaches, and collaborating across multidisciplinary research teams. Depending on experience level, the role may include increasing ownership of study design, assay development, data interpretation, and scientific strategy to support the advancement of engineered cell therapy programs.

• Design, lead, and execute in vitro studies to evaluate engineered cell therapies, including cell identity, functionality, potency, and mechanism-of-action characterization.
• Develop, optimize, and implement novel cellular, molecular, and imaging-based assays to support platform and candidate advancement.
• Independently analyze, interpret, and communicate complex datasets to drive scientific decisions and program strategy.
• Lead microscopy-based characterization efforts, including ICC/IHC, fluorescence and confocal imaging, image analysis, and quantitative phenotyping.
• Identify technical challenges, develop solutions, and drive continuous improvement in experimental approaches and characterization capabilities.
• Collaborate with cross-functional teams and external partners to advance research objectives and support translational studies.
• Contribute to experimental planning, candidate evaluation, and prioritization through scientific insight and critical thinking.
• Maintain high-quality documentation, communicate findings through presentations and reports, and contribute to a collaborative scientific environment.
• Mentor junior scientists and research associates through technical guidance, troubleshooting, and knowledge sharing

• PhD in Cell Biology, Molecular Biology, Pharmacology, Biomedical Sciences, or related field with 0-3 years relevant experience; OR
• MS with 5+ years relevant experience; OR
• BS with 8+ years relevant experience.
• Experience in cell biology, stem cell biology, cell therapy, gene therapy, or related research areas.
• Hands-on experience with cellular, molecular, and functional assay development and execution.
• Experience with fluorescence/confocal microscopy, ICC/IHC, and image analysis.
• Strong experimental design, data analysis, and scientific problem-solving skills.
• Ability to independently plan, execute, and communicate research studies.
• Strong collaboration, organization, and communication skills.

• Experience with retinal biology, ophthalmology, regenerative medicine, or stem cell-derived products.
• Experience with flow cytometry, ELISA/MSD, potency assays, or functional characterization methods.
• Experience in IHC/ICC, microscopy, image analysis
• Demonstrated scientific leadership through independent study ownership, mentorship, or technical leadership.

• This position is based in Westborough, MA and requires on-site work.
• The incumbent is expected to actively participate in experimental design, study execution, data analysis, and scientific discussions.
• The role involves collaboration with internal and external stakeholders in a highly collaborative research environment.

• Global…