Global Program Lead, Immune-Oncology and Immunology

Company Overview

ModeX Therapeutics, an OPKO Health company, is the leading clinical‑stage biopharmaceutical company developing unique and proprietary multispecific therapeutics. Its MSTAR platform unites the power of multiple biologics in a single molecule to create multispecific antibodies that bind four or more targets with unprecedented versatility and potency for complex diseases. Its promising first‑in‑class immunology pipeline includes candidates against immune diseases, including cancer (both solid and hematologic tumors), immune impairment, as well as several of the world’s most pressing viral threats.

Its founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients. ModeX is based in Weston, Massachusetts. For more information, please visit

The Global Program Lead will lead integrated program strategy and coordinate execution for assigned immunology and/or immune‑oncology program(s).

The Global Program Lead reports to the Chief Medical Officer and serves as the accountable leader for assigned project(s), working in partnership with functional leaders across Research, Clinical Development, Clinical Operations, Regulatory, CMC, PK/PD, Safety, Medical, Project Management, and external collaborators. The Global Program Lead manages the assigned project, leads the project team, and is accountable for integrated project decisions, cross‑functional alignment, program execution, and milestone delivery within approved strategy.

This role is responsible for translating approved development strategy into a clear, integrated plan and leading the team to execute it. The Global Program Lead will lead the cross‑functional project team, align work across disciplines, surface risks and trade‑offs, and drive progress toward agreed milestones.

The Global Program Lead will not directly supervise functional leaders unless separately assigned. Functional leaders retain accountability for functional standards, technical quality, people management, resource planning, and cross‑project consistency.

The role requires strong clinical development experience and leadership, sound medical knowledge and judgment, disciplined execution, clear communication, collaborative leadership, and the ability to lead in a matrix environment.

• Lead assigned program(s) through cross‑functional project teams.
• Serve as the accountable program leader for integrated strategy, execution coordination, decision preparation, and milestone delivery.
• Coordinate across Research, Clinical Development, Clinical Operations, Regulatory, CMC, PK/PD, Safety, Medical, Project Management, and external partners.
• Build team cohesion, clarify ownership, and drive disciplined follow‑through across functions.
• Ensure program discussions focus on decisions, risks, actions, owners, and timelines.

• Lead integrated development planning for assigned program(s), in partnership with the Chief Medical Officer and functional leaders.
• Coordinate execution of approved clinical development plans.
• Identify key development options, operational implications, timeline dependencies, resource needs, and decision points.
• Prepare recommendations for review by the Chief Medical Officer and appropriate governance forums.
• Support development strategy discussions with internal leadership, external investigators, advisors, and regulatory authorities.

• Partner with Clinical Development, Research, Clinical Operations, Regulatory, Safety, Medical, and Project Management to drive execution of approved plans.
• Be accountable for the integrated design and execution of early‑stage clinical development programs, in partnership with the respective functions.
• Provide input on clinical study data, reports, protocols, development plans, case report forms, and informed consent documents.
• Track progress against key milestones and elevate issues when execution risk, timing risk, cost impact, or strategy implications become material.

• Lead project team meetings and coordinate input from all…