Associate Director, Program Management

Company Overview

ModeX Therapeutics, an OPKO Health company, is the leading clinical-stage biopharmaceutical company developing unique and proprietary‑multispecific therapeutics. Its MSTAR platform unites the power of multiple biologics in a single molecule to create multispecific antibodies that bind four or more targets with unprecedented versatility and potency for complex diseases. Its promising first‑in‑class immunology pipeline includes candidates against immune diseases, including cancer (both solid and hematologic tumors), immune impairment, as well as several of the world's most pressing viral threats.

Its founding team includes globally recognized medical innovators with proven track records of delivering breakthroughs for patients. ModeX is based in Weston, Massachusetts. For more information, please visit

The (Associate) Director, Program Management (PM) is a critical and valued position within the ModeX development team. The primary role of this position includes leading the development team with program head in developing the project strategy, operational and implementation plan, coordinating across development functions, and ensuring timely and on budget execution of the operational plan.

• Partner with Project Leaders to shape project development strategy, long‑range planning, operational approach, and implementation priorities.
• Build and maintain integrated project plans, including timelines, budgets, resources, milestones, value inflection points, risks, and mitigation plans.
• Drive cross‑functional execution by organizing project team activities, enabling effective collaboration, tracking progress, and ensuring alignment across functions.
• Partner with Finance and functional SMEs to develop and monitor project budgets, resourcing plans, and external vendor/CRO needs, escalating issues as appropriate.
• Ensure transparent communication with executive leadership, including proactive updates on strategy, timelines, budget, risks, and needed adaptations.
• Promote operational excellence and foster a collaborative, accountable, and supportive team culture.
• As applicable, manage projects involving alliance or co‑development partners in coordination with alliance management stakeholders.

• Advanced degree in sciences required
• Minimum of 4+ years of experience in clinical development, and 6+ years in biopharma/biotech industry; experiences in clinical trial execution in the oncology and/or autoimmune disease areas are desirable
• Advanced skills and experience in project management, and usage of relevant tools such as MS Project, Smartsheet, or AI enabling tools
• Strong financial acumen with experience in budget planning, forecasting, variance analysis, and supporting financial decision-making.
• Excellent teamwork, communication (verbal and written), organizational, and interpersonal skills
• Self‑motivated, proactive, and able to prioritize and manage multiple projects simultaneously

ModeX Therapeutics is an Equal Opportunity Employer