Senior Medical Director - Biologics

Location: Wilmington, Delaware, USA
Hybrid: 3 days on site

The US Senior Medical Director – Biologics provides US medical leadership for tezepelumab in severe asthma, chronic rhinosinusitis with nasal polyps, eosinophilic esophagitis, chronic obstructive pulmonary disease, and other disease areas of interest. The role is an integral part of the US Core Medical Team (CMT) and is a primary US medical point of accountability for scientific strategy, evidence generation, and external engagement.

This role is ideally suited for a physician or pharmacist with deep expertise in a relevant medical specialty and experience across late-stage development, launch readiness, and post-approval medical excellence. The Senior Medical Director ensures US medical strategy is aligned with global direction while remaining responsive to the healthcare and clinical landscape within the United States.

At AstraZeneca, teams work across global boundaries to make an impact and find answers to complex challenges. This role sits at the heart of that mission, combining scientific depth with strategic leadership to advance care in multiple chronic inflammatory diseases.

Reporting directly to the US Medical Head of tezepelumab, this leader will guide a high-performing team, drive launches, and influence how evidence, access and clinical practice come together to improve outcomes for patients.

• Serve as a US medical lead for tezepelumab activities, accountable for development and execution of the US Brand Medical Plan across pre- and post-approval stages.
• Provide strategic medical input to US brand and launch strategy, ensuring alignment of scientific priorities with patient and clinical needs.
• Translate complex biology, clinical data, and disease state insights into actionable US medical strategies.

• Lead ongoing post-approval medical strategy to support appropriate scientific exchange and optimize patient care.
• Drive Phase 4 and lifecycle management strategy, including real-world evidence (RWE) and effectiveness studies relevant to US clinicians and payers.
• Provide medical mentorship for US publication strategy and congress planning; medical review of promotional and non‑promotional materials.
• US publication management and congress coordination.
• Scientific response strategy and data dissemination.
• Serve as a medical spokesperson for the US brand as appropriate, supporting external scientific discussions and media inquiries.
• Maintain accountability for the evolving US product scientific narrative, incorporating new data, guidelines, and real‑world insights.

• Design and implement a comprehensive US external engagement plan, including:
• External Scientific Experts (ESEs)
• Academic institutions
• Professional societies
• Lead planning and participation in national and regional company‑led advisory boards
• Ensure high‑quality, compliant scientific exchange that advances medical knowledge and education.

• Collaborate with medical evidence and payer teams to build and implement:
• Clinical effectiveness studies
• RWE and health outcomes research
• Provide medical review and governance for Externally Sponsored Research (ESR) proposals.
• Provide medical input into product safety strategy in collaboration with Patient Safety colleagues.
• Ensure compliance with allUS regulatory requirements, FDA standards, PhRMA Code, and AstraZeneca policies.

• Provide clinical education and scientific training for:
• US Field Medical organization
• Cross‑functional partners (commercial, market access, HEOR)
• Act as a trusted US medical advisor to internal team members on disease…