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Research Scientist

Job in Wilmington, New Castle County, Delaware, 19894, USA
Listing for: Prelude Therapeutics Incorporated
Full Time position
Listed on 2026-06-06
Job specializations:
  • Research/Development
    Research Scientist, Drug Discovery
Salary/Wage Range or Industry Benchmark: 80000 - 100000 USD Yearly USD 80000.00 100000.00 YEAR
Job Description & How to Apply Below

Position Summary

We are seeking a highly motivated and innovative Scientist/Senior Research Scientist to join our Oncology Drug Discovery team in a hands‑on, laboratory‑based role. This individual will play a key role in advancing early‑stage discovery programs, from target validation through lead optimization and translational research, with a focus on developing novel therapeutics for cancer treatment.

This is a wet‑lab bench position, where the successful candidate will design and execute experiments directly and independently, generate high‑quality data, and contribute to scientific strategy. The ideal candidate brings deep experimental expertise, a collaborative mindset, and a strong track record of translating biological insights into therapeutic strategies.

Key Responsibilities
  • Independently design and execute hands‑on wet‑lab experiments, including cell‑based and molecular assays, to support oncology drug discovery programs.
  • Drive novel target identification and validation, including mechanistic studies, to support strategic decision‑making across discovery programs.
  • Lead and perform in vitro and in vivo studies, independently generating and analyzing experimental data.
  • Design, develop, and optimize robust cell‑based or biochemical assays to support target validation and drug discovery efforts.
  • Compile, analyze, and clearly present experimental and scientific data to the biology team to support scientific discussions and decision‑making.
  • Interpret complex datasets and provide scientific insights to the biology team.
  • Perform independent literature review to guide experimental design and apply findings to support hands‑on research and program progression.
  • Identify and implement cutting‑edge technologies and experimental approaches.
  • Maintain detailed experimental records and ensure high‑quality, reproducible data generation.
  • Collaborate closely within the biology team and interface with chemistry, translational, bioinformatics, and other interdisciplinary teams.
Qualifications
  • Ph.D. in Cancer Biology, Molecular Biology or related field.
  • 2-5 years of relevant post‑doctoral experience and/or 0-3 years pharmaceutical industry experience.
  • Strong background in oncology biology.
  • Significant hands‑on experience with a broad range of cell‑based assays and molecular techniques.
  • Strong analytical and communication skills.
Preferred Qualifications
  • Experience with small molecules, targeted protein degradation, or biologics research and/or drug discovery.
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