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Sr. Research Scientist – Biochemistry
Job in
Wilmington, New Castle County, Delaware, 19894, USA
Listed on 2026-06-13
Listing for:
Jobs via Dice
Full Time
position Listed on 2026-06-13
Job specializations:
-
Research/Development
Research Scientist, Drug Discovery, Biomedical Science
Job Description & How to Apply Below
Company
Sovereign Technologies
Job TitleSr. Research Scientist – Biochemistry
LocationOnsite, Wilmington, DE
Position OverviewWe are seeking a highly skilled Sr. Research Scientist – Biochemistry to support drug discovery efforts through the design, development, and execution of biochemical and biophysical assays. This role will play a critical part in hit identification, validation, and mechanistic studies for small molecules and other therapeutic modalities.
Key Responsibilities- Design, develop, and execute biochemical assays (e.g., FI, HTRF, FP) and biophysical assays (e.g., SPR, BLI, ITC, DSF)
- Conduct high-throughput screening (HTS) to evaluate compound libraries and characterize binding kinetics (IC₅₀, Kd, kon, koff)
- Troubleshoot assay performance, optimizing for robustness, reproducibility, and scalability
- Analyze and interpret experimental data using tools such as Graph Pad Prism and Genedata
- Support protein expression and purification workflows using chromatography techniques (affinity, ion-exchange, size-exclusion)
- Operate and maintain lab instrumentation including plate readers and automated liquid handling systems
- Maintain accurate documentation using electronic lab notebooks (ELN) and contribute to technical reports and presentations
- Bachelor’s, Master’s, or Ph.D. in Biochemistry, Chemistry, Biophysics, Chemical Biology, or related field
- Strong foundation in enzymology and assay development
- Hands‑on experience in protein purification and biochemical/biophysical characterization
- Proficiency with data analysis tools (Graph Pad Prism, Genedata, or similar)
- Experience working in a laboratory setting with strong attention to detail and documentation
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