Senior Principal Scientific Advisor

For 75 years, Charles River employees have worked together to assist in the discovery, development and safe manufacture of new drug therapies. When you join our family, you will have a significant impact on the health and well-being of people across the globe. Whether your background is in life sciences, finance, IT, sales or another area, your skills will play an important role in the work we perform.

In return, you'll help you build a career that you can feel passionate about.

We are seeking an experienced nonclinical drug development professional to serve as a Senior Principal Scientific Advisor within our Safety Assessment business units.

The Scientific Advisory Services team is seeking an experienced professional to provide strategic scientific guidance for the advancement of innovative medicines from discovery through first-in-human (FIH) studies and clinical development. This position provides opportunities for independent scientific guidance and leadership within multidisciplinary project teams and across functional areas. The role focuses on developing and implementing nonclinical pharmacology and toxicology strategies that support key development milestones, regulatory interactions, and domestic and global registration objectives.

Responsibilities span a broad range of advanced therapeutic modalities, including cell and gene therapies, oligonucleotides, RNA-based therapeutics, antibody-drug conjugates (ADCs), bispecific antibodies, and other advanced and emerging platforms. Expertise in designing and executing integrated nonclinical development programs encompassing pharmacology, toxicology, pharmacokinetics, biodistribution, immunogenicity, and translational sciences is essential. Success in this role requires a strong understanding of global regulatory expectations, sound scientific judgment, and the ability to deliver innovative, risk-based strategies.

This individual will work closely with current and potential clients and internal Charles River functional groups. The person may act as the scientific leader within cross-functional teams to integrate discovery and safety programs. When appropriate, the individual may perform gap analyses, support due diligence procedures, and perform scientific review of discovery and/or safety assessment data or reports. This role provides for recognition throughout the company as a subject matter expert in one or more therapeutic area(s) or class(es) of therapeutic products.

Successful individuals have knowledge of domestic and international regulatory expectations and requirements; and can provide intellectual input in determining the appropriate discovery and nonclinical safety assessment strategy for complex and novel products. There will be opportunities to support department leadership regarding strategy and recruitment. More broadly, one will work closely with Business Development, Client Services, Account Management, Marketing, and Operations by ensuring that clients’ business and scientific needs are understood and efficiently addressed.

In addition to providing scientific and regulatory support in client interactions, the individual will have the ability to an expanded breadth of experience in covering multiple drug modalities and be able to contribute solutions to complex scientific and regulatory issues when situations occur during the conduct of a drug development program. They will be able to lend support to multiple divisions of CRL and assume leadership roles in multidisciplinary teams when required.

Within Charles River, the individual will be able to provide pivotal leadership and guidance to internal working groups, projects, and/or marketing activities when requested.

This position will mainly support potential clients generally located in the Eastern through Pacific Time Zones.

The following are minimum requirements related to the Senior Principal Scientific Advisor position.

• Education: master’s degree or PhD in relevant discipline (toxicology, pharmacology, biology, immunology, etc.).
• Experience: Minimum 20 years’ experience in pharmaceutical/biotech sector, nonclinical contract research or…