Senior Scientist Product Development

Bio Skryb Genomics is a venture-backed startup company focused on bringing new solutions for cellular heterogeneity in both the research and clinical settings. Bio Skryb’s core technology, primary template-directed amplification (PTA), enables even and unbiased coverage of the entire genome during DNA amplification and allows for unprecedented accuracy and uniformity in variant calling. We believe our technology will enable a new generation of single-cell and low-input DNA genomics applications in diverse markets like Cancer Genomics, Preimplantation Genetic Testing (PGT), Neurology, Microbiome Genomics and Minimal Residual Disease testing.

We are seeking a Senior Scientist, Product
Development to join an exciting, fast-growing, and well-financed company to help develop Bio Skryb’s core chemistry and application business in single cell technologies. This role is instrumental in helping shape and innovate these products to provide the most accurate, highest quality multiomic representation of biological states.

The Senior Scientist Product Development role is a full-time, on-site position based in the Raleigh-Durham-Chapel Hill Area. This role is responsible for designing, developing, and optimizing single-cell genomics products and related workflows, from concept through verification and validation. Day-to-day activities include planning and executing laboratory experiments, analyzing and interpreting data, and contributing to the technical roadmap for new and existing products.

The Senior Scientist collaborates with cross-functional teams in R&D, operations, and quality to support technology transfer and ensure products meet performance, scalability, and regulatory expectations. This position also involves documenting experimental results, presenting findings, mentoring junior team members, and helping drive continuous improvement in product development processes.

• Lead experimental design for Product Development, setting scientific direction and having real authority over how the work gets done
• Execute core lab work including Resolve DNA/OME reactions, library prep, and sequencing to support product development programs
• Drive assay verification and validation efforts, ensuring new and existing products meet rigorous standards for accuracy, sensitivity, and reproducibility
• Prepare and deliver external seminars and webinars, sharing our science with the broader genomics community
• Contribute original ideas, novel solutions, and intellectual property that shape Bio Skryb's technology roadmap
• Thrive in a fast paced environment where you set your own timelines and are trusted to drive projects forward with urgency and ownership

• MS or BS in life sciences with 8+ years of experience of relevant assay development experience in industry, or PhD with 3+ years of industry experience
• Experience in analytical method development, qualification/validation
• Excellent oral and written communication skills
• Experience in tech transfer of assays to quality control labs
• Detail orientated and motivated to move the team forward
• Experience with any or all of the following is preferred: flow cytometry, NGS library creation, assay development of single cell biology applications, assay development for genome modification, operating Next generation sequencing systems (i.e. Illumina), and hands-on experience in conducting nucleic acid quantification assays (fluorescence and electrophoretic assays)