Vice President, Clinical Pharmacology, Pharmacometrics and DMPK

Vice President, Clinical Pharmacology, Pharmacometrics and DMPK

Massachusetts - Hybrid

Join our team in a dynamic hybrid role, offering flexibility to work remotely and from our headquarters in Watertown, MA.

COMPANY OVERVIEW:

Disc Medicine is a clinical-stage biopharmaceutical company committed to discovering, developing, and commercializing novel treatments for patients who suffer from serious hematologic diseases. We are building a portfolio of innovative, first-in-class therapeutic candidates that aim to address a wide spectrum of hematologic diseases by targeting fundamental biological pathways of red blood cell biology, specifically heme biosynthesis and iron homeostasis. Disc Medicine values collaboration, professional development, and scientific integrity and promotes an inclusive company culture that empowers and inspires.

POSITION OVERVIEW
:

Reporting to the Senior Vice President, Early Development and Clinical Pharmacology, this foundational leadership role offers the opportunity to further establish and lead the Clinical Pharmacology, Pharmacometrics and DMPK function. The Vice President will be responsible for integrating Clinical Pharmacology, DMPK, and model-informed drug development into the company’s R&D strategy and driving critical development and regulatory decisions across the pipeline. This role will have a significant and lasting impact on the company’s scientific direction and future success.

RESPONSIBILITIES:

• Further establish and lead the Clinical Pharmacology, Pharmacometrics and DMPK function. Define strategic vision, operational frameworks, and best practices tailored to Disc Medicine’s portfolio and R&D goals.
• Lead the clinical pharmacology and DMPK on cross-functional R&D teams, contributing to nonclinical and clinical development plans, study protocols, and decision-making at all stages.
• Apply quantitative methodologies—including population PK/PD, exposure–response modeling, PBPK, and QSP—to inform dose selection, clinical trial design, special population strategies, and regulatory submissions.
• Drive the clinical pharmacology and DMPK strategy for INDs, CTAs, NDAs/BLAs. Oversee related authorship and review of key regulatory documents and engagement with global health authorities.
• Collaborate closely with Clinical Development, Regulatory Affairs, CMC, Innovation, Toxicology, and Biomarker teams to ensure alignment and integration of Clinical Pharmacology and DMPK throughout R&D.
• Maintain expertise in evolving clinical pharmacology and pharmacometrics, and DMPK approaches. Represent Disc Medicine in external scientific forums, regulatory meetings, and industry collaborations.

REQUIREMENTS:

• PhD or Pharm
  
  D in Clinical Pharmacology, DMPK, Pharmaceutical Sciences, or a related scientific discipline.
• 20+ years of relevant industry experience, including 10+ years in a leadership capacity within clinical pharmacology and/or DMPK.
• Track record of supporting research and development programs including leading Clinical pharmacology/DMPK in regulatory filings and successful interactions with global health authorities.
• Expertise in a broad range of Clinical Pharmacology and DMPK areas with comprehensive understand of the applications of modeling and simulation methodologies (e.g., popPK, PBPK, exposure–response, QSP).
• Demonstrated ability to work collaboratively in a cross-functional, matrixed environment and to influence at all levels of the organization.
• Excellent communication skills, including the ability to distill complex scientific analyses into clear, actionable recommendations.

Disc Medicine is an equal-opportunity employer committed to providing all qualified candidates and employees equal opportunities. We offer comprehensive benefits and competitive compensation packages. The Company headquarters are in Watertown, MA, and we provide a flexible work environment.