Senior Scientist , Host Cell Engineering

Position: Senior Scientist I, Host Cell Engineering
Company Description

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, ()  Facebook, Instagram () , X ()  and You Tube.

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Job Description

We are seeking a highly-motivated Senior Scientist to join our multidisciplinary team focused on robust production cell lines to enable Abb Vie's clinical and commercial biologics pipeline. In this exciting lab-based position, the senior scientist will develop next generation mammalian host cell lines, leveraging advanced gene-editing technologies and System Biology knowledge to engineer CHO host cells for enhanced recombinant protein productivity, improved product quality, and streamlined process efficiency.  

In addition, the successful candidate will enable the Biologics' pipeline through production cell line development and characterization and collaboration on cross-functional teams.  

Experience with cutting edge technologies such as CRISPR-Cas9, Cas-Clover, NGS, 'Omics, bioinformatics, system biology, artificial intelligence (AI), machine learning (ML), HT automation, and digitalization for cell line and process optimization are highly preferred.

Responsibilities:

+ Execute the genetic engineering and characterization of CHO host and production cell lines and optimize processes to improve all stages of pipeline development.

+ Identify and implement advanced technologies strategically to support accelerated biological pipeline programs.

+ Conduct general laboratory research proficiently and independently, adapting and troubleshooting experimental designs and equipment to meet research requirements.

+ Apply creative thinking to solve complex problems and promote new technologies, while effectively communicating mission and ideas to diverse audiences.

+ Author and review technical reports; present data to the group and to leadership; read literature; contribute scientific insights to project teams.

+ Collaborate closely with cell line development, cell culture, analytical, purification, and bioinformatics colleagues to meet project timelines

+ Adhere to corporate standards for code of conduct, safety, materials handling, and good documentation practices.

+ The ideal candidate should be able to manage multiple projects across therapeutic disciplines within a dynamic and fast-paced team setting.

Qualifications

+ Bachelor's Degree in Scientific field with at least 10 years of related work;
Master's Degree in Scientific field with at least 8 years of related work; or PhD in Scientific field at least 0-2 years of related work experience.

+ Strong background in cell and molecular biology, with extensive experience with cell culture and aseptic technique.

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Experience with 'omics, genetic engineering, flow cytometry, fluorescence activated cell sorting (FACS), next generation sequencing, expression vector design, bioinformatics, systems biology, machine learning (ML), artificial intelligence (AI), and/or modeling methods is highly desirable.

+ Excellent problem-solving skills including critical and analytical thinking

+ Excellent communication, leadership, and project management skills.  Demonstrated scientific writing skills and strong verbal communication skills.

+ Demonstrated ability to independently design and execute experiments, interpret data, and identify appropriate follow-up strategies.

+ Proven track record of teamwork, adaptability, innovation, initiative, and integrity.  Global mindset to thrive in a diverse culture and environment

+ Interacts well with diverse groups within function and maintain strong working relationships with internal and external collaborators.

+ Ability to multitask and work within timelines in a dynamic fast-paced setting.

Additional Information

Applicable only to applicants applying to a position in any location with pay…