Principal Research Scientist , Multispecifics Engineering

Principal Research Scientist I, Multispecifics Engineering

• Full‑time
• Salary Min: 124500
• Salary Max: 236500
• Workday Global Grade: 19
• Compensation: USD 124,500 - USD 236,500 per year

Abb Vie’s Multispecifics Engineering group is seeking a highly skilled and self‑motivated scientist to support Discovery Biotherapeutics. The role involves engineering, production, and characterization of multispecific biopharmaceutical products across multiple therapeutic areas.

• Design, engineer, and produce multispecific biologics supporting immunology, oncology, and neuroscience programs.
• Represent Multispecifics Engineering in cross‑functional teams, providing project updates, analysis, and advice; recognized expert in multispecific design and production.
• Act as the Biologics Lead for projects, coordinating activities and transitions from hit generation through candidate nomination.
• Identify and solve technical problems independently; conceive and implement innovative research ideas.
• Ensure consistency and quality of technical reports.
• Present original work internally and at scientific conferences; may author or co‑author peer‑reviewed papers or patents.

• PhD or MS in Biochemistry, Biochemical Engineering, or related disciplines.
• 6+ years (PhD) or 12+ years (MS) of experience in multispecific engineering or antibody engineering.
• Experience with protein, biologics, fragments, or multispecifics (bispecifics, trispecifics, bispecific protein fusions) design, expression, and purification.
• In‑depth knowledge of the multispecific landscape, design trends, and therapeutic applications.
• Ability to recognize emerging areas of interest and connect research ideas to advance platforms and programs.
• Excellent organizational skills and the ability to manage multiple projects simultaneously.
• Team‑player mindset with strong verbal and written communication and a can‑do attitude.

• Experience with sequence analysis tools (Vector NTI, Geneious, Genedata).
• Experience with mass spectrometry analysis and software (Protein Metrics).
• Experience coordinating CRO production.
• Expert understanding of current protein expression, separation, and analytical technologies.
• Knowledge of biologic pipeline progression and program management experience.
• Experience managing direct reports and providing performance evaluations and development opportunities.
• Recognized in the scientific community through peer‑reviewed publications and patents.

Abb Vie is an equal‑opportunity employer and is committed to operating with integrity, driving innovation, and serving its community. All qualified individuals are encouraged to apply.