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Sr Scientist II, Multispecific Antibody Engineering, Oncology

Job in Worcester, Worcester County, Massachusetts, 01609, USA
Listing for: ABBVIE
Full Time position
Listed on 2026-07-09
Job specializations:
  • Research/Development
    Research Scientist, Biotech Research
Salary/Wage Range or Industry Benchmark: 109500 - 208500 USD Yearly USD 109500.00 208500.00 YEAR
Job Description & How to Apply Below

Sr Scientist II, Multispecific Antibody Engineering, Oncology

  • Full-time
  • Salary Min: 109500
  • Salary Max: 208500
  • Workday Global Grade: 18
  • Compensation: USD 109,500 - USD 208,500 - yearly

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

Discovery Biotherapeutics at Abb Vie is seeking a highly skilled, self‑motivated scientist to join a dynamic team supporting the design, engineering, and manufacturing of multispecifics. This position will have a significant impact by managing a group of scientists focused on design, production, and characterization of multispecific biopharmaceutical products. The ideal candidate will have extensive experience with biologics and multispecific production platforms, analytical characterization, and a proven track record of implementing multispecific engineering and production strategies to advance early- and late-stage discovery programs in ADCs and immuno‑oncology.

The ideal candidate should also have experience managing a small multispecific engineering team in a discovery setting. The successful applicant will be an enthusiastic, creative scientist who makes tangible contributions to continuous improvement and innovation within the organization.

Key Responsibilities
  • Design, engineer, and produce multispecific biologics to support Abb Vie’s Oncology therapeutic area; apply design and engineering experience with multispecific biologics for ADC and immuno‑oncology applications.
  • Manage a group of scientists within the multispecific team, focusing on the design, production, characterization of multispecific biologics, and management of multispecific inventory.
  • Serve as the biologics lead on multispecific biologics projects, coordinating activities and transitions from hit generation through candidate nomination.
  • Serve as a multispecific engineering representative on cross‑functional teams; recognized as an expert in multispecific design and production.
  • Identify and solve technical problems independently, conceive, and implement innovative processes in research ideas.
  • Present original work internally across departments and at internal and external scientific conferences; may author or co‑author peer‑reviewed scientific papers or patents.
Qualifications
  • PhD or MS degree in Biochemistry, Biochemical engineering or related disciplines (+ (PhD) or 12+ (MS) years of experience in multispecific engineering or antibody engineering)
  • Experience with protein, biologics, fragments, or multispecifics (e.g., bispecifics, trispecifics, bispecific protein fusions) design, expression and purification
  • In‑depth knowledge of the multispecific landscape, trends in design, and application across therapeutic areas including immunology, oncology, and neuroscience
  • Ability to recognize emerging areas of interest in multispecific engineering, antibody engineering, and related fields, and make connections between research ideas to advance platforms and programs
  • Excellent organizational skills and the ability to manage multiple projects simultaneously
  • Team player with the ability to operate in a fast‑paced multi‑disciplinary environment
  • Goal‑oriented team player with excellent verbal and written communication skills and a strong can‑do attitude
Preferred Qualifications
  • Experience with sequence analysis tools (Vector NTI, Geneious, Genedata)
  • Experience with mass spectrometry analysis and software (Protein Metrics)
  • Experience with CRO coordination for production
  • Expert understanding of current state of protein expression, separation, and analytical technologies
  • Extensive knowledge of biologic pipeline progression from exploratory through candidate nomination with program management experience preferred
  • Experience managing direct reports and providing performance evaluations and…
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