Scientist l - LBA; Ligand Binding Assay Ops

Position: Scientist l - LBA (Ligand Binding Assay) Ops
Company Description

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, ()  Facebook, Instagram () , X ()  and You Tube.

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Job Description

We are seeking an independent, knowledgeable, and highly motivated Ligand Binding Assay Scientist (Scientist I) to join the Quantitative Translational and ADME Sciences (QTAS) department at Abbvie Bioresearch Center in Worcester, MA.

The LBA Operations Bioanalytical team at ABC QTAS conducts non-regulated, pre-clinical quantitative bioanalysis assays of large molecule therapeutics like monoclonal antibodies (mAb), multi-specific Abs, antibody-drug conjugates (ADC), antibody oligonucleotide conjugates (AOCs), and fusion proteins for Pharmacokinetic (PK), Pharmacodynamic (PD) and Toxicokinetic (TK) studies using ligand binding assays to support early development and drug discovery efforts.

As a Scientist I, you will be responsible for:
1) Conducting pre-clinical sample analysis using ligand binding assays (MSD, ELISA) manually and using automated liquid handlers
2) Updating sample, protocol, and reagent management systems using electronic tools such as Laboratory Information Management System (rLIMS) and e-notebooks
3) Reporting, discussing, and QC'ing results to project teams which enable pharmacokinetic and pharmacodynamic analysis in support of oncology, immunology, neurology, and other Abb Vie therapeutic portfolios.

The ideal candidate will be a self-motivated, highly adaptable scientist with strong attention to details, has the ability to quickly learn new concepts, and a commitment to clear, consistent communication in a fast-paced, dynamic environment.

Duties & Responsibilities:

+ Analyze samples by ligand binding assays (PK, PD, TK, ADA) using Meso Scale Discovery platform and colorimetric ELISA or other assay platforms.

+ Plan and execute sample analysis based on bioanalytical protocols and in vivo study designs on a variety of biological matrices (tissue lysates, serum, others) from a variety of species (monkey, mouse, rat).

+ Analyze pre-clinical in vivo samples based on a dynamically changing operational schedule.

+ Interpret, present, and discuss assay results; use results to guide analysis and adjust strategy.

+ Perform timely, accurate, and thorough data archiving in ELN and rLIMS.

+ Communicate experimental plans and results effectively, both verbally and in writing during regular lab meetings and with broader teams

+ Actively support day-to-day laboratory operations.

+ Write and update experimental protocols and procedures.

+ Independently and efficiently initiate, design, interpret, and troubleshoot operational assays.

Qualifications

+ Bachelor's degree in biology, biochemistry, pharmacology, or related field with at least 5 years of pharmaceutical experience or MS in mentioned fields with 2+ years of relevant experience.

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Experience with ligand binding workflow and assay development and troubleshooting is required.

+ Strong attention to detail, with demonstrated impact as an independent and self-motivated contributor.

+ Ability to operate and maintain laboratory equipment and reagents/material inventories independently.

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Experience with lab automation is desirable.

+ Proven independence and problem-solving ability.

+ Excellent written and verbal communication skills and ability to draft technical reports.

+ Proficiency with computers and data analysis/documentation software including Excel, LIMS, and ELN.

+ Ability to summarize, communicate, and interpret bioanalytical results.

+ Ability and willingness to work effectively in a highly collaborative and multidisciplinary environment.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

+ The…