Senior Scientist , Quantitative, Translational, and ADME Sciences; QTAS

Position: Senior Scientist I, Quantitative, Translational, and ADME Sciences (QTAS)
Company Description

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, ()  Facebook, Instagram () , X ()  and You Tube.

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Job Description

The Biomarker team of Quantitative Translational ADME Science (QTAS) at Abb Vie in Worcester, MA is seeking an experienced, creative, and highly motivated senior scientist to support bioanalytical method development, validation and preclinical/clinical sample testing for the discovery and development of novel therapies in multiple therapeutic areas. The Biomarker team focuses on PCR-based assays as well as ligand binding assays (LBA) to support exploratory and translational research that enables decision-making.

The ideal candidate should have hands-on experience in a variety of technologies, including but not limited to qPCR, dPCR, ligand binding assays, high sensitivity and multiplex assays, sample processing and handling, etc. The candidate will be a key member of a global non-regulated bioanalysis team that support all Abb Vie therapeutic areas.

Responsibilities:

+ Develop, qualify, and validate robust bioanalytical qPCR and dPCR workflows on a variety of sample matrices from a variety of species.

+ Experienced  with various ligand binding assays on multiple analytical platforms across a variety of sample matrices.

+ Conduct and document appropriately compliant biomarker sample testing to support pre-clinical and clinical studies.

+ Plan and execute in vivo sample analysis based on bioanalytical protocol and study design.

+ Interpret, present, and discuss assay results; use results to guide analysis and adjust strategy. Communicate experimental plans and results effectively, both verbally and in writing during regular lab meetings and with broader teams.

+ Develop effective partnerships with discovery, preclinical safety, clinical pharmacology, and project team representatives in a highly collaborative and innovative environment to deliver high-impact quality data in a timely manner.

+ Evaluate novel, pipeline-enabling, bioanalytical technologies to expand capabilities and enhance efficiency.

+ Maintain timely laboratory notebooks (ELN) and LIMS records in compliance with Abb Vie policies.

+ Strong organization and communication skills, proactive, attention to detail, critical thinking, troubleshooting skills, independence, multitasking, desire to learn new techniques, and contribute to cutting-edge projects.

Qualifications

+ Bachelor's Degree or equivalent education with 10 or more years of relevant experience, Master's Degree or equivalent education with 8 or more years of relevant experience, or PhD (molecular biology, biochemistry, or other related fields, preferred).

+ Extensive and proven experience in PCR-based bioanalytical workflows for pre-clinical and clinical projects, especially in DNA/RNA purification and qPCR, dPCR, etc.

+ Proficiency with computers and data analysis/documentation software including platform specific tools, LIMS, and ELN

+ Working knowledge of LBA (ELISA, MSD, etc.) biomarker bioanalytical assay development, validation, and sample testing workflows to comply with current regulatory standards and best industry practices.

+ Excellent communication skills, and proven ability to work effectively as a member of a multidisciplinary team.

+ Demonstrated capacity to work in a fast-paced environment with meticulous attention to detail, and an ability to handle multiple projects, prioritize work, and meet deadlines.

+ Working knowledge of handling clinical samples is a plus.

+ Working knowledge of automation is a plus.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

+ The compensation range described below is the range of possible…