Senior Scientist, Antibody Repertoire Sequencing & Discovery

• Full-time
• Salary Min: 109500
• Salary Max: 208500
• Workday Global Grade: 18
• Travel:
  Yes, 5% of the Time
• Compensation: USD 109,500 - USD 208,500 - yearly

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us  .

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The Biotherapeutics and Genetics Medicine department within Discovery Research is seeking a highly motivated

Senior

Scientist to join theMolecular

Coreteam at Abb Vie Bioresearch Center (ABC). The ABC site in Worcester, MA, offersaunique setting where Biotherapeuticsdiscovery, development and manufacturing coexist in one location.

The Molecular Corepartnerswith multidisciplinary groups across Abb Vie focused on developing therapies for Immunology, Neurology and Oncology diseases.

We utilize innovative approaches for antibody discovery including in vivo technologies, custom immunization strategies, advanced multiplex screening assays and best-in-class automation platforms to enable successful antibody discovery against complex targets.

As a member of the in vivo antibody discovery group, you will be responsible for optimizing and expanding antibody repertoire sequencing capabilities in antibody discovery, as well as developing innovative methods to help maintain Abb Vie’s industry-leading standards.

The successful candidate will generate original technical ideas and research strategiesforantibodyrepertoiresequencing (Rep Seq) andanalysis.

They willhavetechnical expertise in generating and applying

RepSeq datatotherapeuticantibody discoveryincludingcomputational proficiency enablinghighly effective collaboration with computational scientists.

This is an exciting opportunity to help drive antibody discovery programs within a multidisciplinary research group in a dynamic, fast-paced environment.

Responsibilities:

• Act as scientific and technical expert inantibodyrepertoire sequencing (Rep Seq/AIRR-Seq/BCR-Seq) fortherapeuticantibody discovery and hit expansion–Bulk sequencing, 10X,and other commercial and proprietary platforms.
• Collaborate withcomputationalscientists to optimizerepertoireanalysis and open new avenues forantibodydiscoverythrough repertoire guided machine learning andgenerative design
• Generate, document, and archive repertoire data with appropriate context and metadata to support broader team access andfutureutilization.
• Analyze and interpret results, placing data in proper scientific context through review of relevant literature, and present findings at team meetings.
• Regularly present data, communicate effectively, and coordinate work within a highly matrixed project team environment.
• Demonstrate scientific excellence through dedication to multiple projects in a fast-paced, multidisciplinary environment.
• Exhibit a can-do attitude and strong interpersonal and communication skills when working across multiple functional teams.

Education:

• BS, MS, or PhDinimmunology,molecular biology,biochemistry,bioinformaticsor a related fieldwith typically0-4+ (PhD), 8-10+ (MS), or 10-12+ (BS) yearsofrelevant experience

Required:

• Extensive scientific expertise in immunoglobulin genetics and antibody biology;specifically,the candidate should be well versed inantibody diversity generation (germline genes/V(D)
  J recombination/somatic hypermutation), affinity maturation, andB cell biology.
• Extensive technical expertiseintheisolation and molecular biology of antibody variable region genes for Next-generation Sequencing (NGS) and the capture of Rep Seq/AIRR-Seq/BCR-Seq) data; both for single-chain and paired heavy- and light-chain recovery
• Understanding ofNGS technologies and platforms– Illumina (Next Seq, MiSeq) andPac Bio
• Understanding and proficiency in molecular biology techniques (e.g. PCR,primer design,molecular cloning, Gibson Assembly,…