Scientist Biologics Developability

Scientist II - Biologics Develop ability

The Biologics CMC Develop ability team is an integral part of the Biologics CMC Drug Product Development organization. The team is responsible for identifying biophysical and chemical liabilities in discovery-stage biologic drug candidates to guide lead selection and characterizing key CMC attributes important for biologic drug development.

We are seeking a Scientist III to support biologic drug product development through advanced analytical characterization of therapeutic biologic molecules. This role focuses on LC-MS and chromatography-based analytical characterization, preparation of analytical packages for downstream stakeholders, and assessment of critical quality attributes and molecular characteristics of biologic candidates. The successful candidate will work in a collaborative laboratory environment, generate high-quality analytical data, and contribute to development-stage biologics programs using cutting-edge analytical techniques.

• Biologics characterization using Liquid Chromatography–Mass Spectrometry (LC-MS).
• Liquid chromatography methods (SEC, IEX, RP-HPLC).
• BS/MS/PhD in Biochemistry, Biology, Chemistry (or equivalent) with relevant biopharmaceutical industry experience.

• Perform in-depth LC-MS-based characterization of therapeutic biologic molecules and evaluate post-translational modifications (PTMs).
• Conduct liquid chromatography-based characterization using Size Exclusion Chromatography (SEC), Ion Exchange Chromatography (IEX), and Reverse Phase HPLC (RP-HPLC).
• Execute experimental protocols, collect results, and perform data analysis independently.
• Prepare analytical packages for downstream stakeholders, including Analytical Research & Development (ARD) and Product Research & Development (PRD).
• Analyze experimental data and prepare scientific reports and presentations.
• Maintain electronic laboratory notebooks, protocols, and scientific documentation.
• Support operation, maintenance, calibration of laboratory equipment, and routine laboratory operations.
• Collaborate with cross-functional research and development teams to achieve project goals.
• Build strong relationships across teams supporting biologics development.
• Follow laboratory safety procedures, corporate code of conduct, and documentation compliance standards.

• Experience with Waters Empower software.
• Experience with Protein Metrics software.
• Experience with liquid handling robotic systems and workflow automation.
• Experience with Hamilton or Tecan liquid handling platforms.
• Experience supporting biologic drug development and CMC activities.
• Demonstrated record of independent thinking, creativity, scientific innovation, publications, or technical achievements.
• Strong problem-solving and experimental troubleshooting skills.
• Experience working in downstream biopharmaceutical development environments.

• Strong biologics analytical characterization experience.
• Hands-on expertise with LC-MS and chromatography-based analytical workflows.
• Experience supporting development-stage biologics or Biologics CMC programs.
• Strong industry experience preferred over primarily academic experience.
• Self-motivated with the ability to independently plan and execute experiments.
• Comfortable performing routine analytical laboratory workflows with minimal supervision.

• Biologics analytical characterization experience.
• LC-MS / Mass Spectrometry experience.
• Liquid Chromatography experience.
• Size Exclusion Chromatography (SEC) experience.
• Ion Exchange Chromatography (IEX) experience.
• Reverse Phase HPLC (RP-HPLC) experience.
• Peptide Mapping experience.
• Protein Mass Spectrometry experience.
• Experience with Waters Empower.
• Experience with Protein Metrics.
• Graph Pad and MS Excel proficiency.
• Experience supporting biologics characterization workflows.
• Downstream biopharmaceutical development experience.
• Experience preparing analytical packages for downstream stakeholders.
• Experience limited to small molecules without biologics exposure.
• No liquid chromatography experience.
• Primarily academic experience without relevant biopharmaceutical industry experience.
• PhD candidates with significantly more than approximately 2 years of post-PhD industry experience.
• Master's candidates with approximately 12+ years of experience who may be overqualified.

The Company offers the following benefits for this position, subject to applicable eligibility requirements: medical insurance, dental insurance, vision insurance, 401(k) retirement plan, life insurance, long-term disability insurance, short-term disability insurance, paid parking/public transportation, paid time off, paid sick and safe time, hours of paid vacation time, weeks of paid parental leave, paid holidays annually.