Scientist II, Complex In Vitro Model

Company Description

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

Abb Vie Immunology is dedicated to discovering breakthrough therapies for inflammatory and auto-immune diseases that can meaningfully improve patients’ lives. The Complex In Vitro Model group is seeking a scientist to support the design, execution, and interpretation of in vitro studies on the characterization of drug candidate molecules and the validation of drug targets.

Key Responsibilities

• Design and perform biochemical and cellular studies of drug potency and mechanism of action using primary human blood cells, cell lines and complex in vitro systems such as organoids or organ-on-chip models.
• Analysis, interpret and clearly communicate quantitative data.
• Conduct and organize activities and communicate through oral and written presentations.
• Read and apply relevant scientific literature.
• Maintenance of accurate and current records of research.

• BS or MS in Biological science with focus in Immunology, Biochemistry, Molecular Biology, Cell Biology, or a related discipline with typically 7+ (BS) or 5+ (MS) years of relevant lab experience.
• Proficiency in culturing primary human immune cells, immortalized cell lines, and organ/tissue cultures, including differentiated cells and iPSCs, using standard tissue culture and transwell systems.
• Experience developing and applying complex in vitro models, including co-culture and advanced 3D cellular systems, to support discovery programs.
• Experience designing experiments to study cell signaling, phosphoproteins, second messenger pathways, cell proliferation, gene reporter assays, and soluble mediator release.
• Expertise in ELISA/MSD, alphaLISA, HTRF, PCR, multicolor flow cytometry, high content microscopy, and related methodologies.
• Demonstrated motivation, strong attention to detail, scientific curiosity, and eagerness to learn novel in vitro pharmacology techniques.
• Strong background in statistics with proficiency in spreadsheets and curve-fitting software such as Microsoft Excel and Graph Pad Prism.
• Skilled in leveraging automation to increase assay robustness, improve throughput, and enable miniaturization of experimental workflows.
• Highly collaborative and able to thrive in a fast-paced, cross‑functional, multidisciplinary environment, with strong organizational, communication, and interpersonal skills.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.
  
  Individual compensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible toparticipatein our short-term incentive programs.

Note:

No amount of payis considered to bewages or compensation until such amount is earned, vested, and determinable.

Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent with applicable law.

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit

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