Senior Scientist, siRNA Synthesis

Company Description About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, Facebook, Instagram, X and You Tube.

The Biotherapeutic and Genetic Medicine (BGM) department at Abb Vie is seeking a motivated Principal Research Scientist I to join the growing siRNA team. In this role, you will work with the genetic medicine teams to establish siRNA synthesis, purification, and analytical capabilities. This individual will serve as a subject matter expert in oligonucleotide synthesis and purification, with responsibility for generating high-quality siRNA materials for advancing genetic medicine studies.

• Lead the siRNA synthesis platform to support various stages of siRNA studies.
• Perform solid-phase oligonucleotide synthesis, deprotection, purification, and desalting of siRNA.
• Troubleshoot synthesis and purification challenges to improve yield, purity, and scalability.
• Work closely with the siRNA analytical colleagues to support characterization, data interpretation, and quality assessment of siRNA materials.
• Collaborate closely with the conjugation team to advance siRNA conjugate development and support platform and project objectives.
• Ensure rigorous documentation, data integrity, and compliance with internal quality standards.
• Track emerging technologies and best practices in oligonucleotide and RNA-based therapeutics.
• Mentor junior scientists and contribute to a collaborative, high-performing team environment.

• BS, MS, or PhD in Chemistry, Chemical Biology, Biochemistry, or a related field with typically 0-4+ years (PhD), 8-10+ years (MS), or 10-12+ years (BS) of relevant biotech or pharmaceutical industry experience.
• Proven track record in gram-scale oligonucleotide synthesis using oligonucleotide synthesizers, as well as development of oligonucleotide purification methods using liquid chromatography systems.
• Strong knowledge of oligonucleotide chemistry and RNA chemistry.
• Experience working cross-functionally with analytical and conjugation teams.
• Demonstrated ability to independently solve complex technical problems and drive projects forward.
• Excellent communication, collaboration, and organizational skills.
• Strong track record of presenting scientific data to internal and external stakeholders.

• The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.
  
  Individual compensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/vision insurance and 401(k) to eligible employees.
• This job is eligible toparticipatein our short-term incentive programs.
• This job is may be eligible toparticipatein our long-term incentive programs.

Note:

No amount of payis considered to bewages or compensation until such amount is earned, vested, and determinable.

Theamountandavailabilityof anybonus,commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employeeremainsin the Company'ssoleandabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent with applicable law.

Abb Vie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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