Scientist Analytical Chemistry - Biologics

Scientist Analytical Chemistry - Biologics

Contract:

Worcester, Massachusetts, US

Salary Range: 50.00 - 60.00 | Per Hour

Job Code: 371136

End Date:

Client Industry: Pharmaceutical
Job Title:
Scientist III :

Analytical Chemistry & Biologics
Location:
Worcester, MA 01605
Duration: 3+ months of contract (++ possibility of extension based on performance and business needs)
Pay Rate Range : $50.00 to $60.00 per hour

Top Must Skills

• Perform separation assays such as HPLC/UPLC chromatography.
• Perform LC-MS experiments on intact protein.
• Fundamental understanding of protein structure, post-translational modifications, and analytical methods used for protein characterization.
• Excellent written communication, oral communication, organization, and multitasking skills.

• The
  primary day-to-day need is chromatography/separation and fractionation
  , with particular emphasis on AKTA. The candidate should be able to become productive quickly with minimal training.

Candidates without direct chromatography/separation experience will not be considered.

Direct
AKTA experience is highly valuable
because it will significantly reduce the learning curve.

Strong HPLC/UPLC experience can also be relevant.

• The work involves separation of
  size and charge variants
  , collection of fractions from chromatographic peaks, and downstream characterization of those fractions.

Candidates with only pure small-molecule analytical experience are not preferred because the analytical requirements are substantially different.

• CRO and academic candidates can be considered when their hands-on experience directly aligns with chromatography, fractionation, AKTA, HPLC/UPLC, and biologics characterization.
• The hiring team is looking for someone capable of handling
  complex laboratory work independently
  , rather than a junior candidate who requires extensive training.
• Experience with
  Waters or Agilent HPLC systems
  is a strong positive screening indicator.
• Attention to detail, precision, reliability, and accurate experimental documentation are important indicators of fit.
• Relocation is acceptable, but candidates outside the Worcester area must be able to relocate
  at their own expense and without a lengthy delay
  .
• No over-index on LC-MS alone.While mass spectrometry is relevant to the overall role, the supplier intake specifically identified chromatography/separation as the immediate primary need.
• Candidate submissions should clearly demonstrate the
  specific hands-on techniques performed
  , rather than listing chromatography or biologics only as general skills.

Job Description:

• Our team is responsible for the development, qualification, and execution of analytical methods to provide product and process understanding for biological entities from discovery through commercial stages.
• As a Scientist, you will be a part of the Analytical Characterization Group within the Analytical Development Department.
• The group focuses on providing routine, investigative, and in-depth characterization analyses of biologics to support product and process development for early-phase, late-phase, and commercial programs using liquid chromatography mass spectrometry (LC-MS), spectroscopy and various other biophysical assays.
• The successful candidate will contribute to the development and performance of analytical assays and will contribute to the continuous improvement and innovation within the group and the Analytical Development Department.

• Perform mass spectrometry analyses (i.e., intact/reduced mass analysis by LC-MS and peptide mapping by LC-MS) of biologics to provide sequence verification and post-translational modification profiles.
• Independently perform separation methods (e.g., fractionation & analysis of variants) using HPLC and AKTA.
• Perform biophysical methods (e.g., DSC) of biologics to support characterization studies.
• Design and execute experiments for method development and/or investigations.
• Support process development by performing raw material analysis using vibrational spectroscopy and executing metabolomics experiments using mass spectrometry.
• Generate and communicate precise, reliable, and reproducible data in a timely manner.
• Organize and document experiments and results in an electronic laboratory notebook.
• Draft protocols, method development reports, and technical characterization reports.

• Bachelors or Masters in chemistry, biology, biochemistry or related technical discipline with typically 5+ (BS) or 2+ (MS) years of relevant experience in biotech/pharmaceutical industry setting.
• Hands-on experience with protein mass spectrometry, liquid chromatography, capillary electrophoresis and protein biophysical characterization.
• Knowledge of HPLC or AKTA instrumentation.
• Fundamental understanding of protein structure, post-translational…