Scientist, II

Company Description

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at  Follow @abbvie on Linked In, ()  Facebook, Instagram () , X ()  and You Tube.

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Job Description

Abb Vie's Gastrointestinal(GI)/Immunology Discovery Research group is looking for a highly motivated and experienced in vivo and in vitro pharmacologist to play an integral role in advancing therapeutics to treat inflammatory GI disorders. This position offers an exciting opportunity to understand the pharmacodynamic effects of experimental medicines with GI relevant in vitro and in vivo assays.

The ideal candidate would work within the highly matrixed and collaborative Discovery Immunology team to guide test article screening and assay development as well as build biology packages for early stage programs. Experimental focus will be on developing and leveraging in vivo and in vitro systems to help understand the impact of test articles in mucosal immunity. The candidate is expected to design, execute, interpret and present innovative research to advance programs towards the clinic.

We are seeking a hands-on experimentalist who is proficient with in vivo and in vitro cell biology research and has demonstrated scientific leadership with internal and external stake holders/experts. The expectation is that the candidate would dedicate the majority of their time toward wet lab experimentation, data analysis and presentation. In addition, we are seeking a candidate with excellent written and oral communication skills.

The candidate will have the opportunity to present their results at team and internal/external science meetings. Prior technical experience in IBD mouse models, humanized mice, biologics molecule screening, and handling of human tissue are required.

  Major Responsibilities:

+ Highly autonomous and productive in performing laboratory research and method development, requiring only minimal direction from supervisor

+ Execute on discovery screening funnels for novel test articles

+ Design, execute and analyze in vivo pharmacology studies in colitis or other GI mouse models

+ Prepare and execute experiments with human blood or intestinal tissue

+ Formulate conclusions and design follow-on experiments based on multidisciplinary data

+ Primary author of regulatory documents.

+ Understand and adhere to corporate standards regarding code of conduct, safety, appropriate handling of materials, controlled drug and radioactive compounds, and animal care

Qualifications

+ Bachelor's Degree or equivalent education and typically, 7 years of work experience, Master's Degree or equivalent education and typically 5 years of work experience

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Experience with in vitro and in vivo cell killing endpoints preferred

+ Highly proficient in primary cell culture, including isolation of human and rodent cells and activation with inflammatory stimulation is preferred

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Experience with ex vivo intestinal tissue assays

+ Possess thorough theoretical and practical understanding of own scientific discipline, especially within gastrointestinal physiology and inflammation.

+ Highly proficient and efficient with in vivo techniques such as mouse restraint, PO, RO and IP dosing routes, and rodent necropsy.

Experience with some colitis models or humanize mouse models is required.

+ Technical capabilities including RT-qPCR, Western blot, multi-parameter flow cytometry

+ Demonstrated ability to learn, understand and master new experimental techniques.

+ Demonstrated scientific writing skills and strong verbal communication skills through publication and conference presentations.

Additional Information

​Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: ​

+ The compensation range described below is the range of…