Scientist, II

• Compensation: USD 84500 - USD 162000 - yearly

About Abb Vie

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us  .

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Abb Vie’sGastrointestinal(GI)/Immunology Discovery Research group is looking for a highly motivated and experienced invivo and in vitropharmacologistto play an integral role in advancing therapeutics to treat inflammatory GI disorders.

This position offers an exciting opportunity to understand thepharmacodynamic effectsof experimental medicines with GI relevant in vitro and in vivo assays.

The ideal candidate would work within the highly matrixed and collaborative

Discovery Immunology team toguidetest article screening and assay development as well asbuild biology packages forearly stage programs.

Experimental focus will be on developing andleveragingin vivo and in vitro systems tohelpunderstand the impact of test articlesinmucosal immunity.

The candidate is expected to design, execute,interpret and present innovative research to advance programs towards the clinic.

We are seeking a hands-on experimentalist who isproficientwithin vivo and in vitrocell biology research andhasdemonstratedscientificleadership with internal and external stake holders/experts.

The expectation is that the candidate would dedicate the majority oftheir time toward wet lab experimentation, dataanalysisand  addition, we are seeking a candidate with excellent written and oral communication skills.

The candidate will have the opportunity to present their results at team and internal/external science meetings.

Priortechnicalexperience inIBDmouse models, humanized mice,biologicsmolecule screening, and handling of human tissuearerequired.
Major Responsibilities:

Highly autonomous and productive in performing laboratory research and method development, requiring only minimal direction from supervisor

Execute on discovery screening funnels fornovel test articles

Design, execute and analyze in vivopharmacologystudies in colitis or other GI mouse models

Prepare and execute experiments withhuman blood or intestinal tissue

Formulate conclusions and design follow-on experiments based on multidisciplinary data

Primary author of regulatory documents.

Understand and adhere to corporate standardsregardingcode of conduct, safety,appropriate handling of materials, controlled drug and radioactive compounds, and animal care

Bachelor’s Degree or equivalent education and typically,7years ofworkexperience,Master’s Degreeor equivalent education and typically5years of work experience

Experience within vitro and in vivocell killing endpoints preferred

Highly proficient in primary cell culture, including isolation of human and rodent cells and activation with inflammatory stimulation is preferred

Experience with ex vivo intestinal tissue assays

Possess thorough theoretical and practical understanding ofownscientific discipline, especially within gastrointestinal physiology and inflammation.

Highly proficient and efficient within vivo techniques such as mouse restraint, PO, ROand IP dosing routes, and rodent necropsy.

Experience with some colitis modelsor humanize mouse modelsisrequired.

Technical capabilities including RT-qPCR,Western blot,multi-parameterflowcytometry

Demonstrated ability to learn,understand and master new experimental techniques.

Demonstrated scientific writing skills and strong verbal communication skills through publication and conference presentations.

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Company believes ingood faith it will pay for this role at thetimeofthis posting based on the job grade for this position.
  
  Individual compensation paid within this range will depend on many factors including geographic location,andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays,…