Clinical Director; Principal Scientist), Translational Medicine, Immunology

Translational Medicine (Immunology) Principal Scientist / Medical Director – Level

Translational Medicine is responsible for early clinical development of novel therapeutics.

• Lead early clinical development strategy from Preclinical Candidate approval through Clinical Pharmacology (Phase
  1) and clinical Proof‑of‑Concept (Phase
  2).
• Develop biomarker strategies via cross‑functional teams, from First‑in‑Human through Proof‑of‑Concept; include Experimental Medicine to establish/validate biomarker platforms.
• Partner with discovery research to incorporate clinical perspective into target identification/validation; execute clinical studies to evaluate target relevance to human disease.
• Develop and execute clinical pharmacology strategies to support Proof‑of‑Concept (Phase
  2) through worldwide marketing application.
• Serve as a key member of an early development team; design and execute early clinical development strategy.
• Author initial clinical and biomarker plans (Lead Optimization), early clinical development plans (Preclinical Candidate molecules), and clinical pharmacology studies (Phases I–IV).
• Validate clinical platforms using established/novel biomarkers (imaging, electrophysiological, and behavioral responses in humans).
• Provide clinical expertise for target/pathway validation (preclinical and/or clinical pharmacology experiments).
• Ensure safe, timely Phase I execution; collaborate with discovery research, biostatistics, drug metabolism, modeling/simulation, regulatory affairs, and global clinical trials operations.
• Support submissions for worldwide marketing application filings (registration documents and presentations).
• Communicate and interpret study results to governance/expert groups and development review committees.
• Interface broadly with Discovery Sciences, Preclinical Pharmacology, Pharmaceutical Sciences, Toxicology, Translational Biomarkers, Translational Medicine Operations/EU, Drug Metabolism/Modeling & Simulation, Regulatory Affairs, and late‑stage Clinical Research.

MD or MD/PhD.

• Proven track record in clinical medicine or clinical research; background in biomedical research.
• Demonstrated scientific scholarship (publications/presentations); collaborative mindset across therapeutic areas.
• Strong interpersonal, writing, and presentation skills.

• Clinical Board Certification or eligibility.
• Experience in translational research and/or early clinical development.
• Proven track record in clinical care or management of clinical problem‑solving.

• Clinical Development
• Clinical Judgment
• Clinical Research/Studies/Trials
• Clinical Trial Support
• Cross‑Functional Teamwork
• Early Clinical Development
• Immunology
• Intellectual Curiosity
• Translational Medicine
• Translational Research

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