Scientist, Preclinical Dev

Scientist, Preclinical Dev.

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Apply remote type:
Hybrid locations:
USA
- Pennsylvania
- West Pointtime type:
Full time posted on:
Posted Todaytime left to apply:
End Date:
June 30, 2026 (13 days left to apply) job requisition :
R401886
** Job Description
**** Role

Summary:

** Vaccines and Advanced Biotechnologies Process R&D (VaxPRD) is responsible for the development and clinical manufacturing of Drug Substance (DS) and Drug Product Intermediates (DPI) for the vaccine and advanced therapy pipeline, spanning from preclinical to commercialization stages. We are part of the Process R&D organization, which enables modality-agnostic DS/DP process development and clinical manufacturing for our company's pipeline. Our vaccines upstream process development team develops safe, scalable, robust, cost-effective upstream processes that enable clinical and commercial manufacture of vaccines and adjuvants across all vaccine modalities.

Under the direction of the group leader, the individual will be responsible for upstream process development of vaccine candidates. The successful candidate will plan, perform, and critically evaluate lab scale process development and scale-up studies, develop robust, efficient, scalable processes for vaccine production, and support transfer of processes to clinical or commercial manufacturing facilities. The individual is expected to function in a multidisciplinary environment, contributing subject matter expertise to teams engaged in development and clinical manufacture of vaccine candidates.

This position requires the employee to be willing to work with infectious agents and/or pathogens and may require occasional travel and off-hour/weekend work.
** Key Responsibilities
*** Design, execute, and analyze process development experiments to maximize understanding of cell culture and fermentation processes to enable robust vaccine manufacturing.
* Conduct laboratory bench work to execute, optimize, and troubleshoot cell culture and fermentation processes (e.g., shake flasks, bench scale and pilot scale bioreactors).
* Apply data analysis and basic data science/modeling approaches (e.g., statistics, design of experiments) to design experiments, interpret datasets, and support process understanding and optimization.
* Contribute to the development and scale‐up of upstream processes from lab scale to pilot scale and support technology transfer to manufacturing scale.
* Perform upstream unit operations as needed, including lab scale cell culture, fermentation, centrifugation, filtration, and in-process assays.
* Maintain and coordinate raw material and equipment inventories; ensure equipment is operated and maintained in a safe, compliant manner.
* Prepare clear technical reports and presentations to summarize and communicate experimental results and recommendations in a collaborative team environment.
* Mentor and provide technical guidance to contract staff or new hires in laboratory techniques and best practices, as appropriate.
* Keep accurate, detailed laboratory records; comply with all required training and maintain a strong focus on laboratory/facility safety for self and team members.
* Contribute to the development of new principles, concepts, and methods to enable process development, scale-up of processes to pilot scale, and technology transfer to…