U.S. Sales Operations Lead

Pharvaris is a Nasdaq listed late‑stage biotech company developing bradykinin B2 receptor antagonists for bradykinin‑mediated diseases, with offices in Switzerland (Zug), the Netherlands (Leiden) and the U.S.A. (greater Boston area). We aim at bringing new, more convenient options to Hereditary Angioedema (
HAE) patients who suffer sudden and prolonged attacks of swelling in multiple areas of the body including the airway, which can be life‑threatening. We have a culture built on the core values of considering others carefully, leading with trust, ensuring rigor and diversity of thought, and contributing freely. Our company is driven by individuals committed to developing breakthrough therapies which can have a real impact on people’s lives.

If you are looking for a place where your work can have meaning, and you can make a difference – Pharvaris is the place for you!

As we are expanding the U.S. Commercial team, we are looking for a U.S. Sales Operations Lead
, to join our team and report to the Head of Commercial Operations, North America.

The U.S. Sales Operations Lead will be responsible for building and managing the operational backbone that enables the success of Pharvaris’ sales organization. This role will lead core sales operations functions including incentive compensation, territory design and alignment, targeting, sales reporting, operational forecasting, analytics, go‑to‑market planning, and budget management.

At Pharvaris we promote and enable a flexible hybrid work environment, where our employees choose from where (and to some extent when) they prefer to work. Whilst this is a remote/hybrid role, you need to be in the U.S. (East coast preferably).

• Design, implement, and manage sales incentive compensation plans that align with business goals and motivate compliant performance.
• Oversee IC modeling, tracking, and payout processes with accuracy and timeliness.

• Develop initial territory structures and targeting lists to support launch and optimize coverage.
• Maintain ongoing territory alignments, adjustments, and mapping in coordination with field leadership.

• Partner with U.S. Marketing and Sales leads to develop, build, automate, deliver, and maintain dashboards and reports to track sales performance, field activity, and market trends.
• Deliver actionable insights to leadership to inform strategic decisions.

• Contribute to launch readiness efforts, ensuring alignment across field force deployment, targeting, and performance metrics.
• Support scenario modeling for different GTM strategies.

• Partner with Marketing, Market Access, and Patient Services to align operational plans.
• Support ad‑hoc projects that enhance commercial effectiveness and execution.

• Bachelor’s degree; MBA or advanced degree a plus.
• 7+ years of pharmaceutical/biotech sales operations, analytics, or commercial strategy experience; rare disease experience strongly preferred.
• Demonstrated expertise in incentive compensation, territory design/alignment, forecasting, and sales analytics.
• Experience with CRM, data visualization tools (Tableau, Power BI), and Excel modeling.
• Proven ability to work in fast‑paced, entrepreneurial environments with evolving priorities.
• Strong business acumen, analytical skills, and problem‑solving capabilities.
• Excellent communication and collaboration skills; ability to influence across functions.

• Patient‑First mindset that puts patients at the center while balancing purpose and performance.
• Big picture thinking through connecting the cross‑functional dots, anticipates what is next and drives strategy.
• Strong influencing skills and can build trust‑based partnerships and thrive in a fast‑paced environment.
• Drive for results, by being ambitious, resilient and committed in pursuing excellence where it matters most.
• Strong problem‑solving skills and can turn complex matters into clarity, someone that can easily and quickly adept and is driven by continuous learning.
• Integrity…