Associate Director, Global Health Economics & Outcomes Research; RWE

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH), a serious liver disease that can progress to cirrhosis, liver failure, need for liver transplantation and premature mortality. Every member of our Madrigal team is connected by our shared purpose: leading the fight against MASH.

Madrigal’s medication, Rezdiffra (resmetirom), is a once-daily, oral, liver-directed THR-β agonist designed to target key underlying causes of MASH. Rezdiffra is the first and only medication approved by both the FDA and European Commission for the treatment of MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial is evaluating Rezdiffra for the treatment of compensated MASH cirrhosis (F4c).

Our success is driven by our people. We are building a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration. To support our continued growth, we are strengthening our workforce strategy to ensure we have the right talent, at the right time, in the right way.

The Associate Director, Global Health Economics & Outcomes Research (GHEOR), Real-World Evidence (RWE) will support the strategic goals of the GHEOR, Global Medical Affairs (GMA) and the broader business driving patient access with optimal pricing and reimbursement for Madrigal Pharmaceutical’s medicines, with a focus on Rezdiffra.

This position directly impacts the ability to achieve business objectives on a global basis by providing strategic guidance and robust evidence development relevant to achieve optimal patient access by demonstrating the value of our medicines for liver health, with a primary focus on developing and deploying real-world data and evidence to support Rezdiffra and the Madrigal portfolio, in a federated operating model that includes service delivery across the enterprise.

This role will be responsible for developing and executing RWE projects and strategies against the global integrated evidence plans, including dissemination of technical deliverables related to real-word data and evidence. The role will also support the design and execution of pragmatic, prospective real-world and implementation science studies to evaluate treatment effectiveness, care delivery and adoption of evidence-based practices in routine clinical settings.

Reporting to the Senior Director, GHEOR (RWE), the incumbent will be working closely with the GMA, Clinical Development & Biostatistics, Access and Commercial, Regional and in-Country teams to foster a culture that promotes innovation, optimal population health and patient centricity.

All incumbents are responsible for adhering to applicable Madrigal policies and procedures.

Approximately 60% of this role focuses on executing functional objectives, and the remaining 40% is dedicated to providing support for strategic direction and adapting priorities to achieve organizational goals.

• Evidence Generation and HEOR Studies
  • Analyze complex real-world data (RWD) sources such as administrative claims and electronic health records databases
  • Design, build, and maintain internal data warehouses
  • Develop and maintain reproducible analytical pipelines and real-world evidence (RWE) platforms using R programming, leveraging version control tools and collaborative coding environments (e.g., Git Hub), while integrating SQL and Python where beneficial
  • Build and govern internal real-world data (RWD) analytics infrastructure by leveraging modern platforms such as Posit Workbench and Databricks to enable end-to-end RWE study execution
  • Execute both rapid analyses and full protocol-driven research studies, including…