Vice President, Early Clinical Development, Radiopharmaceutical Therapies Remote - United State

Position: Vice President, Early Clinical Development, Radiopharmaceutical Therapies Remote - United State[...]
## Vice President, Early Clinical Development, Radiopharmaceutical Therapies Remote - United States - USFind out how well you match with this job
** Working with Us
** Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it.

You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: , a Bristol Myers Squibb company, is a dynamic biotechnology company headquartered in San Diego, CA.

The company is focused on improving survival of people with cancer by harnessing the power of targeted radioisotopes. Rayze Bio is developing innovative drugs against targets of solid tumors. Led by a successful and experienced entrepreneurial team, Rayze Bio aims to be the global leader in radiopharmaceuticals.
** Position Summary
** This role will report to the CMO and hold a key leadership position within the clinical development organization and will serve as the bridge between research, discovery, and clinical development. The Vice President of Early Development will lead the clinical strategy and medical oversight for the Rayze Bio portfolio of next-generation radiopharmaceutical therapies. This role is responsible for the "First-in-Human" journey, transforming preclinical discoveries into robust, data-driven clinical programs that demonstrate early safety, biological activity, and therapeutic potential.

This role provides medical direction and high quality scientific and clinical knowledge to lead the strategy and execution of Rayze Bio’s clinical development plans for molecules in early development. Responsibilities include support for IND preparation, regulatory authority interactions, design and execution of Phase 0/1 FIH clinical trials. This role will lead cross-functional teams responsible for the design, implementation, monitoring, analysis, and reporting of studies conducted within Rayze Bio’s portfolio to ensure the program meets the needs of patients and Rayze Bio’s business.

This role will engage with BMS oncology leaders in research and early clinical development to develop combination strategies as appropriate across the BMS and Rayze Bio portfolios.
** Key Responsibilities
*** Clinical Development Strategy:
Design and execute innovative Phase 0/1 clinical trials. Define the clinical path to proof-of-concept, including the use of theranostic pairs to accelerate patient selection.
* Translational & Medical Oversight:
Lead the translation of preclinical pharmacology and toxicology into First-in-Human dosing strategies. Serve as the primary medical/scientific voice for the early-stage pipeline.
* Dosimetry & PK/PD:
Collaborate with medical physicists to integrate radiation dosimetry into clinical protocols, ensuring optimized therapeutic windows and individualized patient safety.
* Imaging Strategy:
Define the imaging strategy to provide early evidence of target engagement, biodistribution, and tumor response.
* Regulatory Liaison:
Act as the lead clinical expert for meetings with global health authorities (FDA/EMA). Draft and defend clinical sections of IND/CTA filings, with a focus on justifying dose-escalation schemes and safety monitoring. Support and lead interactions with the FDA’s Division of Medical Imaging and Radiation Medicine.
* KOL

Collaboration:

Establish a network of academic investigators and nuclear medicine specialists to ensure strategic alignment with changes in therapeutic landscapes and collaboration on early development programs
* Portfolio strategy:
Le…